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900600

Sigma-Aldrich

3-(Fluorosulfonyl)-5-((trimethylsilyl)ethynyl)benzoic acid

≥95%

Synonym(s):

Carboxyl sulfonyl fluoride alkyne, Probe building block

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About This Item

Empirical Formula (Hill Notation):
C12H13FO4SSi
CAS Number:
Molecular Weight:
300.38
MDL number:
UNSPSC Code:
12352106
NACRES:
NA.22

assay

≥95%

form

solid

reaction suitability

reagent type: cross-linking reagent

availability

available only in USA

storage temp.

−20°C

SMILES string

O=S(C1=CC(C#C[Si](C)(C)C)=CC(C(O)=O)=C1)(F)=O

Application

3-(Fluorosulfonyl)-5-((trimethylsilyl)ethynyl)benzoic acid is used for chemical probe synthesis, this trifunctional building block contains an aryl sulfonyl fluoride group, alkyne tag, and carboxylic acid synthetic handle. When appended to a ligand or pharmacophore through its acid linker, this building block allows for SuFEx-enabled, context-specific covalent modification of a biological target with potential for downstream applications via the alkyne tag. Use alone or in parallel with other multi-functional building blocks to discover the optimal probe for your chemical biology experiments.

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pictograms

FlameExclamation mark

signalword

Danger

Hazard Classifications

Eye Irrit. 2 - Self-react. C - Skin Irrit. 2

Storage Class

5.2 - Organic peroxides and self-reacting hazardous materials

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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