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900858

Sigma-Aldrich

2-(Prop-2-yn-1-yloxy)-4-(3-(trifluoromethyl)-3H-diazirin-3-yl)benzoic acid

≥95%

Synonym(s):

Carboxyl diazirine alkyne, Probe building block

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About This Item

Empirical Formula (Hill Notation):
C12H7F3N2O3
CAS Number:
Molecular Weight:
284.19
UNSPSC Code:
12352106
NACRES:
NA.22

Quality Level

assay

≥95%

form

powder

reaction suitability

reaction type: click chemistry

storage temp.

−20°C

SMILES string

C#CCOC1=CC(C2(N=N2)C(F)(F)F)=CC=C1C(O)=O

Application

2-(Prop-2-yn-1-yloxy)-4-(3-(trifluoromethyl)-3H-diazirin-3-yl)benzoic acid is used for chemical probe synthesis, this trifunctional building block contains a light-activated diazirine, alkyne tag, and carboxylic acid synthetic handle. When appended to a ligand or pharmacophore through its acid linker, this building block allows for UV light-induced covalent modification of a biological target with potential for downstream applications via the alkyne tag. Use alone or in parallel with other multi-functional building blocks to discover the optimal probe for your chemical biology experiments.

related product

Product No.
Description
Pricing

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificates of Analysis (COA)

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Articles

In partnership with Pfizer chemists, we have compiled a collection of trifunctional building blocks to enable development of probes.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

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