900865

4-Formyl-2-((trimethylsilyl)ethynyl)benzenesulfonyl fluoride

≥95%

• Synonym(s): Formyl sulfonyl fluoride TMS-Alkyne, Probe building block
• Empirical Formula (Hill Notation): C₁₂H₁₃FO₃SSi
• CAS Number: 2088829-01-8
• Molecular Weight: 284.38
• UNSPSC Code: 12352200
• NACRES: NA.22

Properties

• assay: ≥95%
• form: powder or crystals
• reaction suitability: reaction type: click chemistry
• storage temp.: −20°C
• SMILES string: O=CC1=CC=C(S(=O)(F)=O)C(C#C[Si](C)(C)C)=C1

Description

Application

4-Formyl-2-((trimethylsilyl)ethynyl)benzenesulfonyl fluoride is used for chemical probe synthesis, this trifunctional building block contains an aryl sulfonyl fluoride group, alkyne tag, and aldehyde synthetic handle. When appended to a ligand or pharmacophore through its formyl linker, this building block allows for SuFEx-enabled, context-specific covalent modification of a biological target with potential for downstream applications via the alkyne tag. Use alone or in parallel with other multi-functional building blocks to discover the optimal probe for your chemical biology experiments.

Other Notes

Technology Spotlight: Trifunctional Probe Building Blocks

Chemoselective Preparation of Clickable Aryl Sulfonyl Fluoride Monomers: A Toolbox of Highly Functionalized Intermediates for Chemical Biology Probe Synthesis

Safety Information

• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable