900750

(4-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)phenyl)(4-(prop-2-yn-1-yloxy)phenyl)methanone HCl salt

≥95%

• Synonym(s): Amino (PEG)₃ benzophenone alkyne HCl salt, Probe building block
• Empirical Formula (Hill Notation): C₂₂H₂₅NO₅ · HCl
• Molecular Weight: 419.90
• UNSPSC Code: 12352200
• NACRES: NA.22

Properties

• Quality Level: 100
• assay: ≥95%
• form: powder
• reaction suitability: reaction type: click chemistry
• storage temp.: −20°C
• SMILES string: [H]Cl.O=C(C1=CC=C(OCC#C)C=C1)C2=CC=C(OCCOCCOCCN)C=C2

Description

Application

(4-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)phenyl)(4-(prop-2-yn-1-yloxy)phenyl)methanone HCl salt is used for chemical probe synthesis, this trifunctional building block contains a light-activated benzophenone, alkyne tag, and amine synthetic handle. When appended to a ligand or pharmacophore through its PEGylated amine linker, this building block allows for UV light-induced covalent modification of a biological target with potential for downstream applications via the alkyne tag. Use alone or in parallel with other multi-functional building blocks to discover the optimal probe for your chemical biology experiments.

Other Notes

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A library approach to rapidly discover photoaffinity probes of the mRNA decapping scavenger enzyme DcpS

Investigating γ-secretase protein interactions in live cells using active site-directed clickable dual-photoaffinity probes

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable