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924490

Sigma-Aldrich

Hyaluronic acid methacrylate

Low Viscosity, Low Endotoxin, 0.2 um sterile filtered, 0.2 μm, sterile-filtered

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Synonym(s):
HAMA, Hyaluronan, Hyaluronic acid, MeHA
Linear Formula:
(NaC20H28NO15)n

Quality Level

description

Validation : HNMR at 40°C

sterility

sterile-filtered

form

(Solid chunks, fibers or powder)

impurities

≤10 CFU/g Bioburden (Fungal)
≤10 CFU/g Bioburden (Total Aerobic)
100 EU/g Endotoxin

color

white to pale yellow

particle size

0.2 μm

storage temp.

2-8°C

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This Item
924474B1557919624
Sigma-Aldrich

Sigma-Aldrich

924474

Hyaluronic Acid

Sigma-Aldrich

Sigma-Aldrich

919624

TissueFab® bioink 

impurities

≤10 CFU/g Bioburden (Fungal), ≤10 CFU/g Bioburden (Total Aerobic), 100 EU/g Endotoxin

impurities

<10 CFU/g Bioburden, <100 EU/g Endotoxin

impurities

-

impurities

<5 CFU/g Bioburden (Fungal), <5 CFU/g Bioburden (Total Aerobic)

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

-

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

description

Validation : HNMR at 40°C

description

-

description

-

description

suitable for 3D bioprinting applications

sterility

sterile-filtered

sterility

-

sterility

-

sterility

sterile-filtered

Application

Hyaluronic acid (HA) is a linear polysaccharide of alternating D-glucuronic acid and N-acetyl-D-glucosamine found primarily in connective tissues. HA based hydrogels are widely used in tissue engineering, 3D bioprinting, and drug deliery applications. The methacrylate functionalized hyaluronic acid is photo-crosslinkable, and can be used to generate crosslinked hydrogels.

Packaging

1EA = 500 mg of lyophilized material in glass bottle.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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25G
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MMYOMAG-74K-13

1000309185

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Stiffness and adhesivity control aortic valve interstitial cell behavior within hyaluronic acid based hydrogels.
Duan, et al.
Acta Biomaterialia, 9, 7640-7650 (2018)
Micromolding of shape-controlled, harvestable cell-laden hydrogels.
Yeh, et al.
Biomaterials, 27, 5391-5398 (2007)
Photocrosslinkable Hyaluronan-Gelatin Hydrogels for Two-Step Bioprinting
Skardal, et al.
Tissue Engineering: Part A, 16 (8) (2010)
Influence of Three-Dimensional Hyaluronic Acid Microenvironments on Mesenchymal Stem Cell Chondrogenesis
Chung and Burdick
Tissue Engineering: Part A, 15(2) (2009)
Judy Yeh et al.
Biomaterials, 27(31), 5391-5398 (2006-07-11)
Encapsulation of mammalian cells within hydrogels has great utility for a variety of applications ranging from tissue engineering to cell-based assays. In this work, we present a technique to encapsulate live cells in three-dimensional (3D) microscale hydrogels (microgels) of controlled

Articles

Engineered ECMs enhance immune therapy in cancer treatment by supporting cells and tissues and modulating immune response. They improve immune cell maturation, expansion, and regulation through biomaterial manipulation, acting as frameworks or carriers for enhanced tumor immunotherapy.

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