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D-085

Supelco

Dexamethasone solution

1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

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Empirical Formula (Hill Notation):
C22H29FO5
CAS Number:
Molecular Weight:
392.46
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24

grade

certified reference material

Quality Level

form

liquid

feature

Snap-N-Spike®/Snap-N-Shoot®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

concentration

1.0 mg/mL in methanol

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

application(s)

clinical testing

format

single component solution

storage temp.

−20°C

SMILES string

C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CO

InChI

1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1

InChI key

UREBDLICKHMUKA-CXSFZGCWSA-N

Gene Information

human ... NR3C1(2908)

General description

Dexamethasone is a potent glucocorticoid which acts as an anti-inflammatory and immunosuppressant for therapeutic treatments in many inflammatory and autoimmune conditions, oncology, and endocrine diseases such as Addison′s disease. Dexamethasone levels in serum or plasma are measured by LC-MS/MS for dexamethsaone suppression tests or monitoring dexamethsaone treatment regimens. This Certified Spiking Solution® is suitable for use as starting materials in the preparation of calibrators and controls for dexamethasone testing methods by LC-MS/MS.

Application

  • Controlled drug delivery systems: Hydrogel microneedles incorporating dexamethasone demonstrate a programmed mesophase transition, optimizing the controlled release of drugs for therapeutic applications. This advancement in drug delivery technology illustrates the utility of dexamethasone solution in developing innovative pharmaceutical materials (Dawud et al., 2024).
  • Enhanced nasal drug administration: Bovine Serum Albumin nanoparticles, integrated with dexamethasone, highlight a novel gelling system designed to enhance nasal drug delivery. This research underscores the potential of dexamethasone solution in creating more effective and patient-friendly drug delivery modalities (Mardikasari et al., 2023).
  • Sustained-release formulations: The development of polyvinyl alcohol microparticles for the sustained release of dexamethasone via a coaxial microfluidic system demonstrates the critical role of dexamethasone solution in producing precision drug delivery systems that improve therapeutic efficacy and patient compliance (Abdi Majareh et al., 2023).
  • Topical drug delivery for ocular conditions: Dexamethasone-loaded chitosan nanoparticles were developed for topical application in a rabbit model of endotoxin-induced uveitis, indicating significant advancements in localized drug delivery systems using dexamethasone solutions. This application is particularly relevant in treating inflammatory eye diseases with enhanced drug delivery efficiency (Alkholief et al., 2023).

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

related product

Product No.
Description
Pricing

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

target_organs

Eyes,Central nervous system

wgk_germany

WGK 2

flash_point_f

49.5 °F

flash_point_c

9.7 °C


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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USP

USP

1177000

Dexamethasone phosphate

Cortisone solution 100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

Supelco

C-130

Cortisone solution

Dexamethasone tested according to Ph. Eur.

Sigma-Aldrich

31375

Dexamethasone

Erich Piovan et al.
Cancer cell, 24(6), 766-776 (2013-12-03)
Glucocorticoid resistance is a major driver of therapeutic failure in T cell acute lymphoblastic leukemia (T-ALL). Here, we identify the AKT1 kinase as a major negative regulator of the NR3C1 glucocorticoid receptor protein activity driving glucocorticoid resistance in T-ALL. Mechanistically
Shankar Swaminathan et al.
Journal of biomedical nanotechnology, 9(6), 998-1007 (2013-07-19)
Nanosponges (NS) were synthesized by crosslinking of beta cyclodextrins with diphenyl carbonate. It is a hyper-branched polymer with an ultra high encapsulation efficiency leading to formation of colloidal systems. Dexamethasone (DEX) on the other hand is a poorly soluble drug
Valentina Proserpio et al.
Genes & development, 27(11), 1299-1312 (2013-06-12)
Elucidating the epigenetic mechanisms underlying muscle mass determination and skeletal muscle wasting holds the potential of identifying molecular pathways that constitute possible drug targets. Here, we report that the methyltransferase SMYD3 modulates myostatin and c-Met transcription in primary skeletal muscle
Peter Bärtsch et al.
The New England journal of medicine, 368(24), 2294-2302 (2013-06-14)
A 45-year-old healthy man wishes to climb Mount Kilimanjaro (5895 m) in a 5-day period, starting at 1800 m. The results of a recent exercise stress test were normal; he runs 10 km 4 or 5 times per week and
Jeroen J H Bunge et al.
American heart journal, 168(1), 126-131 (2014-06-24)
The postpericardiotomy syndrome (PPS) is a common complication following cardiac surgery. The pathophysiology remains unclear, although evidence exists that surgical trauma and the use of cardiopulmonary bypass provoke an immune response leading to PPS. We hypothesized that an intraoperative dose

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