Glutathione (reduced)

suitable for biopharmaceutical production EMPROVE® bio Ph Eur

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Glutathione (reduced), γ-L-Glutamyl-L-cysteinglycine, GSH
Empirical Formula (Hill Notation):
CAS Number:
Molecular Weight:
MDL number:
EC Index Number:


Ph. Eur.

Quality Level

product line



3 (20 °C, 10 g/L in H2O)


185-195 °C


100 g/L

bulk density

160 kg/m3



storage temp.




InChI key


General description

Our SAFC® portfolio of high-quality products for biopharmaceutical processing withstands strict quality control procedures and is produced according to MQ-500 requirements as defined by the M-Clarity program.

M-Clarity Program

As part of our EMPROVE® Program, our raw materials are offered with EMPROVE® Dossiers which provide comprehensive, up-to-date documentation to help you navigate regulatory challenges, manage risks, and improve your manufacturing processes.

Our comprehensive portfolio of downstream process chemicals not only provides biopharmaceutical manufacturers with high-quality raw materials for production of classical and novel therapies, but also helps them get to market faster and simplify regulatory challenges. Ranging from non-GMP grades for low-risk application, to IPEC-PQG GMP for higher-risk applications, we have products covering all your manufacturing needs.

Analysis Note

Assay (iodometric, calc. on dried substance): 98.0 - 101.0 %
Identity (IR-spectrum): passes test
Appearance: white to almost white, slightly agglomerated, crystalline powder
Appearance of solution (100 g/l, water): clear and colorless.
Spec. rotation (α 20/D, 40 g/l, water, calc. on dried substance): -15.5° to -17.5°
Chloride (Cl): ≤ 200 ppm
Sulfate (SO₄): ≤ 300 ppm
As (Arsenic): ≤ 1.5 ppm
Fe (Iron): ≤ 10 ppm
Fe (Iron) (ICP): ≤ 10 ppm
NH₄ (Ammonium): ≤ 200 ppm
Cu (Copper)*: ≤ 25 ppm
Related substances (CE) (Impurity A (Cysteinylglycine)): ≤ 0.5 %
Related substances (CE) (Impurity B (Cysteine)): ≤ 0.5 %
Related substances (CE) (Impurity C (Glutathione oxidized)): ≤ 1.5 %
Related substances (CE) (Impurity D (Glutamylcysteine)): ≤ 1.0 %
Related substances (CE) (Impurity E): ≤ 0.5 %
Related substances (CE) (Largest unspecified impurity): ≤ 0.2 %
Related substances (CE) (Sum of all impurities): ≤ 2.5 %
Acetic acid (HS-GC): ≤ 5000 ppm
Ethanol (HS-GC): ≤ 5000 ppm
Ethyl acetate (HS-GC): ≤ 5000 ppm
Other residual solvents (ICH Q3C): passes test
Sulfated ash (600 °C): ≤ 0.1 %
Loss on drying (105 °C; 3 h): ≤ 0.5 %
Elemental impurity specifications have been set considering ICH Q3D (Guideline for Elemental Impurities). Class 1-3 elements are not likely to be present above the ICH Q3D option 1 limit, unless specified and indicated (*).
Corresponds to Ph. Eur.

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids



Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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