3541

Glutathione, Reduced, Free Acid

>98% (titration), solid, endogenous antioxidant, Calbiochem^®

• Synonym(s): Glutathione, Reduced, Free Acid, γ-Glu-Cys-Gly, GSH
• Empirical Formula (Hill Notation): C₁₀H₁₇N₃O₆S
• CAS Number: 70-18-8
• Molecular Weight: 307.32
• MDL number: MFCD00065939
• UNSPSC Code: 12352209
• NACRES: NA.25

Properties

• product name: Glutathione, Reduced, Free Acid, Glutathione, Reduced, Free Acid, CAS 70-18-8, is a tripeptide that serves as an endogenous antioxidant and provides protection against auto-oxidation.
• Quality Level: 200
• assay: >98% (titration)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; desiccated (hygroscopic)
• color: white
• solubility: water: 1 mg/mL; DMF: 10 mg/mL; ethanol: 5 mg/mL
• shipped in: ambient
• storage temp.: 2-8°C
• InChI: 1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)
• InChI key: RWSXRVCMGQZWBV-UHFFFAOYSA-N

Description

General description

Glutathione is a tripeptide composed of cysteine, glycine, and glutamic acid. In cells glutathione either exists as reduced (GSH) and oxidized (GSSG). The ratio of glutathione reduced (GSH) to glutathione oxidized (GSSG) determines the cell’s redox status. Healthy resting cells have a GSH/GSSG ratio >100. In cells under oxidative stress, the GSH/GSSG ratio drops to between 1 and 10. Glutathione has also been identified as the thiol buffer that keeps sulfohydryl groups in the reduced form of many proteins. It is produced solely in the cytochrome P450 system and actively pumped to mitochondria. GSH depletion can lead to Neurodegenerative disorders, Pulmonary disease, Immune diseases, Cardiovascular diseases, Chronic age-related diseases, Liver disease, Cystic fibrosis and Aging process itself.

Application

Glutathione, Reduced, Free Acid has been used to elute the GST-OTUD6A proteins after purification using Glutathione Sepharose.

Biochem/physiol Actions

Cell permeable: no

Product does not compete with ATP.

Reversible: no

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable