Skip to Content
MilliporeSigma
All Photos(1)

Key Documents

219557

Sigma-Aldrich

Cerulenin

from Cephalosporium caerulens, ≥98% (TLC), solid, de novo phospholipid synthesis inhibito, Calbiochem

Synonym(s):

Cerulenin, Cephalosporium caerulens

Sign Into View Organizational & Contract Pricing


About This Item

Empirical Formula (Hill Notation):
C12H17NO3
CAS Number:
Molecular Weight:
223.27
MDL number:
UNSPSC Code:
41106500
NACRES:
NA.77

product name

Cerulenin, Cephalosporium caerulens, An antifungal antibiotic that inhibits sterol and fatty acid biosynthesis.

Quality Level

assay

≥98% (TLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

white to off-white

solubility

DMSO: 10 mg/mL
ethanol: 5 mg/mL
acetone: soluble

shipped in

ambient

storage temp.

2-8°C

InChI

1S/C12H17NO3/c1-2-3-4-5-6-7-8-9(14)10-11(16-10)12(13)15/h2-3,5-6,10-11H,4,7-8H2,1H3,(H2,13,15)/b3-2+,6-5+/t10-,11-/m1/s1

InChI key

GVEZIHKRYBHEFX-NQQPLRFYSA-N

General description

An anti-fungal antibiotic that inhibits fatty acid biosynthesis by binding, in equimolar ratio, to β-keto-acyl-ACP synthase. Also inhibits sterol synthesis by blocking the activity of HMG-CoA synthetase activity. Systemic and intracerebroventricular of this compound reduces feeding and induces weight loss.
An antifungal antibiotic that inhibits sterol and fatty acid biosynthesis. In fatty acid synthesis, reported to bind in equimolar ratio to β-keto-acyl-ACP synthase. In sterol synthesis, inhibits HMG-CoA synthetase activity. Also shown to inhibit feeding and induce dramatic weight loss in mice.

Biochem/physiol Actions

Primary Target
sterol & fatty acid biosynthesis

Packaging

Packaged under inert gas

Warning

Toxicity: Harmful (C)

Other Notes

Loftus, T.M., et al. 2000. Science288, 2379.
Inokashi, J., et al. 1994. Mol. Gen. Genet. 244, 90.
Schneider, F., et al. 1993. Biochim. Biophys. Acta 1152, 243.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

Exclamation mark

signalword

Warning

hcodes

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Verena Baumann et al.
The Journal of cell biology, 223(7) (2024-04-04)
Autophagy serves as a stress response pathway by mediating the degradation of cellular material within lysosomes. In autophagy, this material is encapsulated in double-membrane vesicles termed autophagosomes, which form from precursors referred to as phagophores. Phagophores grow by lipid influx
Byungil Kim et al.
Molecular cell, 78(4), 624-640 (2020-05-08)
The primary interactions between incoming viral RNA genomes and host proteins are crucial to infection and immunity. Until now, the ability to study these events was lacking. We developed viral cross-linking and solid-phase purification (VIR-CLASP) to characterize the earliest interactions

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service