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524488

Sigma-Aldrich

Phloretin

A cell-permeable inhibtor of protein kinase C (IC₅₀ = 20-50 µM).

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Synonym(s):
Phloretin, 2ʹ,4ʹ,6ʹ-Trihydroxy-3- p-hydroxyphenylpropiophenone, 2ʹ,4ʹ,6ʹ-Trihydroxy-3-p-hydroxyphenylpropiophenone
Empirical Formula (Hill Notation):
C15H14O5
CAS Number:
Molecular Weight:
274.27
MDL number:

Quality Level

assay

≥97% (TLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

white

solubility

acetone: soluble
ethanol: soluble
methanol: soluble

shipped in

ambient

storage temp.

−20°C

InChI

1S/C15H14O5/c16-10-4-1-9(2-5-10)3-6-12(18)15-13(19)7-11(17)8-14(15)20/h1-2,4-5,7-8,16-17,19-20H,3,6H2

Inchi Key

VGEREEWJJVICBM-UHFFFAOYSA-N

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This Item
440025527948208925
Phloretin A cell-permeable inhibtor of protein kinase C (IC₅₀ = 20-50 µM).

524488

Phloretin

Luteolin An antioxidant flavonoid and a free radical scavenger.

440025

Luteolin

Piceatannol A cell-permeable, substrate competitive and reversible plant metabolite that inhibits the activity of rat liver protein kinase A catalytic subunit (IC₅₀ = 3 µM), PKC (IC₅₀ = 8 µM), MLCK (IC₅₀ = 12 µM).

527948

Piceatannol

assay

≥97% (TLC)

assay

≥90% (HPLC)

assay

≥95% (HPLC)

assay

≥95% (HPLC)

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

acetone: soluble, methanol: soluble

solubility

aqueous base: 1.4 mg/mL, DMSO: 7 mg/mL, ethanol: soluble

solubility

DMSO: 10 mg/mL, ethanol: 10 mg/mL

solubility

DMSO: 10 mg/mL, methanol: 40 mg/mL

General description

A cell-permeable inhibtor of protein kinase C (IC50 = 20-50 µM). Activates Ca2+-activated K+ channels in amphibian myelinated nerve fibers at micromolar concentrations. An inhibitor of myo-inositol uptake. Also inhibits L-type Ca2+ channel activity. A potent inhibitor of 5′-iodothyronine deiodinase. Antagonist of prostaglandin F receptors linked to phospholipase C in astrocytes.

Biochem/physiol Actions

Cell permeable: yes
Product does not compete with ATP.
Reversible: no
Target IC50: 20-50 µM against protein kinase C

Warning

Toxicity: Irritant (B)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Ethanol stock solutions are stable for up to 1 month at -20°C.

Other Notes

Berry, G.T., et al. 1994. Pediat. Res.35, 141.
Koh, D.S., et al. 1994. Neurosci. Lett. 165, 167.
Morreale de Escobar, G., et al. 1994. Endocrinology134, 2410.
Prevarskaya, N., et al. 1994. Mol. Cell. Neurosci.5, 699.
Kitanaka, J., et al. 1993. J. Neurochem.60, 704.
Wang, X., et al. 1993. Biochem. J.290, 249.
Benga, G., et al. 1992. Eur. J. Cell Biol.59, 219.
Jordan, M.L., and Wright, J. 1991. J. Surg. Res.50, 569.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

Exclamation mark

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable


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