MilliporeSigma
All Photos(1)

Documents

539160

Sigma-Aldrich

Proteasome Inhibitor I

The Proteasome Inhibitor I controls the biological activity of Proteasome. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

Sign Into View Organizational & Contract Pricing

Synonym(s):
Proteasome Inhibitor I, PSI
Empirical Formula (Hill Notation):
C32H50N4O8
Molecular Weight:
618.76

Quality Level

assay

≥90% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

white

solubility

DMSO: 30 mg/mL
ethanol: 30 mg/mL
methanol: soluble

shipped in

ambient

storage temp.

−20°C

Compare Similar Items

View Full Comparison

Show Differences

1 of 4

This Item
53916211836153001CO-RO
vibrant-m

539160

Proteasome Inhibitor I

vibrant-m

539162

Proteasome Inhibitor II

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Roche

manufacturer/tradename

Roche

Quality Level

100

Quality Level

100

Quality Level

-

Quality Level

-

form

solid

form

lyophilized solid

form

tablet

form

tablet

storage condition

OK to freeze

storage condition

OK to freeze, desiccated

storage condition

-

storage condition

-

color

white

color

white

color

-

color

-

General description

A cell-permeable, reversible inhibitor of the chymotrypsin-like activity of the multicatalytic proteinase complex (MCP; 20S proteasome) in HT4 cells. Causes the accumulation of ubiquitinated proteins in neuronal cells. Prevents the activation of NF-κB in response to TNF-α and Okadaic Acid (Cat. No. 495604) through inhibition of IκB-α degradation. A 50 mM (5 mg/162 µl) solution of Proteasome Inhibitor I (Cat. No. 539161) in DMSO is also available.
Cell-permeable inhibitor of the chymotrypsin-like activity of the multicatalytic proteinase complex (MCP; 20S proteasome) in HT4 cells. Causes the accumulation of ubiquitinylated proteins in neuronal cells. Prevents NF-κB activation in response to TNFα and okadaic acid through inhibition of IκB-α degradation, thereby interfering with induction of iNOS in macrophages.

Biochem/physiol Actions

Cell permeable: yes
Primary Target
Chymotrypsin-like activity of the multicatalytic proteinase complex (MCP; 20S proteasome) in HT4 cells
Product does not compete with ATP.
Reversible: yes

Warning

Toxicity: Standard Handling (A)

Sequence

Z-Ile-Glu(OtBu)-Ala-Leu-CHO

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 3 months at -20°C.

Other Notes

Griscavage, J.M., et al. 1996. Proc. Natl. Acad. Sci. USA93, 3308.
Mori, S., et al. 1995. J. Biol. Chem.270, 29447.
Figueiredo-Pereira, M.E., et al. 1994. J. Neurochem. 63, 1578.
Traenckner, E.B., et al. 1994. EMBO J. 13, 5433.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Documents related to the products that you have purchased in the past have been gathered in the Document Library for your convenience.

Visit the Document Library

Difficulty Finding Your Product Or Lot/Batch Number?

Product numbers are combined with Pack Sizes/Quantity when displayed on the website (example: T1503-25G). Please make sure you enter ONLY the product number in the Product Number field (example: T1503).

Example:

T1503
Product Number
-
25G
Pack Size/Quantity

Additional examples:

705578-5MG-PW

PL860-CGA/SHF-1EA

MMYOMAG-74K-13

1000309185

enter as 1.000309185)

Having trouble? Feel free to contact Technical Service for assistance.

Lot and Batch Numbers can be found on a product's label following the words 'Lot' or 'Batch'.

Aldrich Products

  • For a lot number such as TO09019TO, enter it as 09019TO (without the first two letters 'TO').

  • For a lot number with a filling-code such as 05427ES-021, enter it as 05427ES (without the filling-code '-021').

  • For a lot number with a filling-code such as STBB0728K9, enter it as STBB0728 without the filling-code 'K9'.

Not Finding What You Are Looking For?

In some cases, a COA may not be available online. If your search was unable to find the COA you can request one.

Request COA

Customers Also Viewed

Slide 1 of 7

1 of 7

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service