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539165

Sigma-Aldrich

Proteasome Inhibitor Set II

The Proteasome Inhibitor Set II controls the biological activity of Proteasome. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

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Quality Level

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

shipped in

ambient

storage temp.

−20°C

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Proteasome Inhibitor Set II The Proteasome Inhibitor Set II controls the biological activity of Proteasome. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

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Proteasome Inhibitor Set II

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MAP Kinase Inhibitor Set II The MAP Kinase Inhibitor Set II controls the biological activity of MAP Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

444190

MAP Kinase Inhibitor Set II

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage condition

OK to freeze, protect from light

storage condition

OK to freeze

storage condition

OK to freeze, desiccated

storage condition

OK to freeze, protect from light

shipped in

ambient

shipped in

ambient

shipped in

ambient

shipped in

ambient

General description

Contains 5 mg of ALLN (Cat. No. 208719), 100 μg each of Epoxomicin (Cat. No. 324800), and clasto-Lactacystin β-Lactone (Cat. No. 426102). Supplied with a data sheet.
Proteasomes are large multi-subunit protease complexes, which selectively degrade intracellular proteins. A protein marked for degradation is attached to multiple molecules of ubiquitin, a 76-amino acid protein, which escorts it for rapid hydrolysis, by the 26S proteasome. The proteolytic core of this complex consists of the 20S proteasome, which contains multiple peptidase activities and has a molecular mass of ~700 kDa. Recently several potent, cell-permeable proteasome inhibitors have been developed.



The Calbiochem brand offers a set that includes 3 proteasome inhibitors with varying inhibtory effects.



The table below outlines some of the physical and biological properties of these compounds.

Biochem/physiol Actions

Primary Target
calpain 1, calpain 2
Secondary Target
cathepsin B, cathepsin L

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3


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