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539164

Sigma-Aldrich

Proteasome Inhibitor Set I

The Proteasome Inhibitor Set I controls the biological activity of Proteasome. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

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Quality Level

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

shipped in

ambient

storage temp.

−20°C

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This Item
539165539160539162
vibrant-m

539164

Proteasome Inhibitor Set I

vibrant-m

539165

Proteasome Inhibitor Set II

vibrant-m

539160

Proteasome Inhibitor I

vibrant-m

539162

Proteasome Inhibitor II

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

form

solid

form

solid

form

solid

form

lyophilized solid

shipped in

ambient

shipped in

ambient

shipped in

ambient

shipped in

ambient

storage condition

OK to freeze

storage condition

OK to freeze, protect from light

storage condition

OK to freeze

storage condition

OK to freeze, desiccated

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

General description

Proteasomes are large multi-subunit protease complexes, localized in the nucleus and cytosol, which selectively degrade intracellular proteins. They play a major role in the degradation of many proteins involved in cell cycling, proliferation, and apoptosis. A vast majority of short-lived proteins are degraded by the ubiquitin-proteasome pathway. A protein marked for degradation is covalently attached to multiple molecules of ubiquitin (Ubq), a highly conserved 76-amino acid (8.6 kDa) protein, which escorts it for rapid hydrolysis to the multi-component enzymatic complex known as the 26S proteasome. The proteolytic core of this complex, the 20S proteasome, contains multiple peptidase activities and functions as the catalytic machine.



The ubiquitin-proteasome pathway plays a major role in the breakdown of abnormal proteins that result from oxidative stress and mutations that might otherwise disrupt normal cellular homeostasis. The reactive oxygen species can promote partial unfolding of the proteins, exposing its hydrophobic domains to proteolytic enzymes of the 20S complex. Rapid degradation of defective enzymes, as seen in diseases caused by metabolic abnormalities, also occurs in the proteasome. The Ubq-proteasome pathway has also been implicated in several forms of malignancy, in the pathogenesis of several genetic diseases, and in the pathology of muscle wasting. It is also involved in the destruction of proteins that participate in cell cycle progression, transcription control, signal transduction, and metabolic regulation.

Biochem/physiol Actions

Primary Target
MPC
Secondary Target
NF-κB activity

Warning

Toxicity: Standard Handling (A)

Other Notes

Grimm, L.M., et al. 1996. EMBO J.15, 3835.
Griscavage, J.M., et al. 1996. Proc. Natl. Acad. Sci. USA93, 3308.
Lee, D.H., and Goldberg, A.L. 1996. J. Biol. Chem.271, 27280.
Oda, K., et al. 1996. Biochem. Biophys. Res. Commun.219, 800.
Fenteany, G., et al. 1995. Science268, 726.
Traenckner, E.B., et al. 1994. EMBO J.13, 5433.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3


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