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869001-M

Sigma-Aldrich

Follicle Stimulating Hormone, Human Pituitary, Iodination Grade

Follicle Stimulating Hormone, Human Pituitary, Iodination Grade, CAS 9002-68-0, is a native pituitary protein that regulates Sertoli cells by acting on G-protein-linked cell surface FSH receptors.

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Synonym(s):
Follicle Stimulating Hormone, Human Pituitary, Iodination Grade, Follitropin, hFSH
CAS Number:
MDL number:

biological source

human pituitary glands

Quality Level

sterility

non-sterile

product line

Calbiochem®

Assay

≥90%

form

lyophilized solid

specific activity

≥2000 IU/mg

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

impurities

≤0.1% hCG
≤0.5% hLH, hTSH

pI 

4.1

solubility

PBS: soluble

storage temp.

−20°C

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This Item
F4021869006-M869008-M
sterility

non-sterile

sterility

non-sterile

sterility

non-sterile

sterility

-

product line

Calbiochem®

product line

-

product line

-

product line

-

assay

≥90%

assay

-

assay

≥95% (weight)

assay

≥97% (weight)

form

lyophilized solid

form

powder

form

lyophilized solid

form

lyophilized solid

storage condition

OK to freeze

storage condition

-

storage condition

OK to freeze

storage condition

OK to freeze

General description

Follicle-stimulating hormone (FSH) belongs to the family of glycoprotein hormones. It is synthesized in the gonadotrophs present in the pituitary gland. FSH contains non-covalently associated α- and β-subunits and is a disulfide-rich heterodimer.

Research area: Cell Signaling

Biochem/physiol Actions

Follicle-stimulating hormone (FSH) participates in the regulation of reproduction in mammals. It exerts its effects through a G-protein-coupled receptor known as follicle-stimulating hormone receptor (FSHR) that is located on the granulosa cells of the ovaries and Sertoli cells of the testes. FSH plays a role in the maturation of ovarian follicles in females and supports spermatogenesis by activating Sertoli cell proliferation in males. The interaction of FSH with its receptor FSH-R leads to the activation of G-protein coupled receptors/cyclic adenosine monophosphate (cAMP)/protein kinase A pathways to transmit intracellular signals.

Warning

Toxicity: Carcinogenic / Teratogenic (D)

Preparation Note

Prepared from tissue of individuals that have been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Costrici, N., et al. 1995. Endocrinology136, 4705.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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T R Kumar et al.
Nature genetics, 15(2), 201-204 (1997-02-01)
Follicle stimulating hormone (FSH) is a member of the glycoprotein hormone family that includes luteinzing hormone (LH), thyroid stimulating hormone, and chorionic gonadotropin. These heterodimeric hormones share a common alpha subunit and differ in their hormone-specific beta subunit. The biological
Qing R Fan et al.
Nature, 433(7023), 269-277 (2005-01-22)
Follicle-stimulating hormone (FSH) is central to reproduction in mammals. It acts through a G-protein-coupled receptor on the surface of target cells to stimulate testicular and ovarian functions. We present here the 2.9-A-resolution structure of a partially deglycosylated complex of human
Alfredo Ulloa-Aguirre et al.
Endocrinology, 159(8), 3020-3035 (2018-07-10)
FSH is synthesized in the pituitary by gonadotrope cells. By binding to and interacting with its cognate receptor [FSH receptor (FSHR)] in the gonads, this gonadotropin plays a key role in the control of gonadal function and reproduction. Upon activation

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