AB2218
Anti-Aquaporin 4 Antibody
Chemicon®, from rabbit
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All Photos(3)
Synonym(s):
AQP4, WCH4, MIWC
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Recommended Products
biological source
rabbit
Quality Level
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
purified by
affinity chromatography
species reactivity
human, mouse, rat
manufacturer/tradename
Chemicon®
technique(s)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Gene Information
human ... AQP4(361)
General description
The water-specific channel Aquaporin 4 is located in various tissues including the gastro intestinal tract, kidney and brain. It is an osmoreceptor which regulates body water balance and mediates water flow within the central nervous system. The localization of AQ4 to astrocyte endfeet makes it an excellent marker for astrocyte distal processes.
Specificity
Recognizes Aquaporin 4.
The antibody has not yet been tested for cross-reactivity to other species. The immunogen shows 94% similarity to mouse, 88% to bovine, 86% to rabbit and 82% to human AQP4 (hAQP4).
Immunogen
Epitope: C-Terminus
Synthetic Linear Peptide
Application
Anti-Aquaporin 4 Antibody is an antibody against Aquaporin 4 for use in WB.
Research Category
Neuroscience
Neuroscience
Research Sub Category
Ion Channels & Transporters
Ion Channels & Transporters
Western Blotting: 0.5-1 μg/mL using Chemiluminescence technique.
Optimal working dilutions must be determined by end user.
Optimal working dilutions must be determined by end user.
Target description
~34 kDa
Linkage
Replaces: AB3068
Physical form
ImmunoAffinity Purified
Purified in PBS with 0.05% NaN3
Storage and Stability
Maintain at 2-8°C in undiluted aliquots for up to 1 year after date of receipt.
Analysis Note
Control
Tested on adult rat brain lysate
Tested on adult rat brain lysate
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
recommended
Product No.
Description
Pricing
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Stefanie Gurnik et al.
Acta neuropathologica, 131(5), 753-773 (2016-03-05)
The homeostasis of the central nervous system is maintained by the blood-brain barrier (BBB). Angiopoietins (Ang-1/Ang-2) act as antagonizing molecules to regulate angiogenesis, vascular stability, vascular permeability and lymphatic integrity. However, the precise role of angiopoietin/Tie2 signaling at the BBB
Christina Stefanitsch et al.
Frontiers in cellular neuroscience, 9, 456-456 (2015-12-10)
The serine protease tissue-type plasminogen activator (tPA) is used as a thrombolytic agent in the management of ischemic stroke, but concerns for hemorrhagic conversion greatly limits the number of patients that receive this treatment. It has been suggested that the
Alvaro Cobo-Calvo et al.
PloS one, 15(9), e0238301-e0238301 (2020-09-04)
Neuromyelitis optica spectrum disorders (NMOSD) is a primary astrocytopathy driven by antibodies directed against the aquaporin-4 water channel located at the end-feet of the astrocyte. Although blood-brain barrier (BBB) breakdown is considered one of the key steps for the development
Romain Marignier et al.
Brain : a journal of neurology, 133(9), 2578-2591 (2010-08-07)
Devic's neuromyelitis optica is an inflammatory demyelinating disorder normally restricted to the optic nerves and spinal cord. Since the identification of a specific autoantibody directed against aquaporin 4, neuromyelitis optica-immunoglobulin G/aquaporin 4 antibody, neuromyelitis optica has been considered an entity
Erika Bindocci et al.
Science (New York, N.Y.), 356(6339) (2017-05-20)
Astrocyte communication is typically studied by two-dimensional calcium ion (Ca2+) imaging, but this method has not yielded conclusive data on the role of astrocytes in synaptic and vascular function. We developed a three-dimensional two-photon imaging approach and studied Ca2+ dynamics
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