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AB2218

Sigma-Aldrich

Anti-Aquaporin 4 Antibody

Chemicon®, from rabbit

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Synonym(s):
AQP4, WCH4, MIWC
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

100

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

human, mouse, rat

manufacturer/tradename

Chemicon®

technique(s)

western blot: suitable

NCBI accession no.

NM_001650.4
NM_004028.3

UniProt accession no.

P55087

shipped in

wet ice

Gene Information

human ... AQP4(361)

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Anti-Aquaporin 4 Antibody Chemicon®, from rabbit

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Anti-Aquaporin-4 Antibody, clone mCCD clone mCCD, from mouse

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Anti-Aquaporin 4 Antibody, CT

Anti-Aquaporin-4 Antibody from rabbit, purified by affinity chromatography

Sigma-Aldrich

ABN411

Anti-Aquaporin-4 Antibody

antibody form

affinity isolated antibody

antibody form

purified antibody

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

clone

polyclonal

clone

mCCD, monoclonal

clone

polyclonal

clone

polyclonal

species reactivity

human, mouse, rat

species reactivity

human, rat, mouse

species reactivity

mouse, human, rat

species reactivity

mouse, rat, human

manufacturer/tradename

Chemicon®

manufacturer/tradename

-

manufacturer/tradename

Chemicon®

manufacturer/tradename

-

technique(s)

western blot: suitable

technique(s)

immunocytochemistry: suitable, immunohistochemistry: suitable, immunoprecipitation (IP): suitable, western blot: suitable

technique(s)

immunohistochemistry: suitable, western blot: suitable

technique(s)

western blot: suitable

General description

The water-specific channel Aquaporin 4 is located in various tissues including the gastro intestinal tract, kidney and brain. It is an osmoreceptor which regulates body water balance and mediates water flow within the central nervous system. The localization of AQ4 to astrocyte endfeet makes it an excellent marker for astrocyte distal processes.

Specificity

Recognizes Aquaporin 4.
The antibody has not yet been tested for cross-reactivity to other species. The immunogen shows 94% similarity to mouse, 88% to bovine, 86% to rabbit and 82% to human AQP4 (hAQP4).

Immunogen

Epitope: C-Terminus
Synthetic Linear Peptide

Application

Anti-Aquaporin 4 Antibody is an antibody against Aquaporin 4 for use in WB.
Research Category
Neuroscience
Research Sub Category
Ion Channels & Transporters
Western Blotting: 0.5-1 μg/mL using Chemiluminescence technique.

Optimal working dilutions must be determined by end user.

Target description

~34 kDa

Linkage

Replaces: AB3068

Physical form

ImmunoAffinity Purified
Purified in PBS with 0.05% NaN3

Storage and Stability

Maintain at 2-8°C in undiluted aliquots for up to 1 year after date of receipt.

Analysis Note

Control
Tested on adult rat brain lysate

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

recommended

Product No.
Description
Pricing

Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

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Erika Bindocci et al.
Science (New York, N.Y.), 356(6339) (2017-05-20)
Astrocyte communication is typically studied by two-dimensional calcium ion (Ca2+) imaging, but this method has not yielded conclusive data on the role of astrocytes in synaptic and vascular function. We developed a three-dimensional two-photon imaging approach and studied Ca2+ dynamics
Romain Marignier et al.
Brain : a journal of neurology, 133(9), 2578-2591 (2010-08-07)
Devic's neuromyelitis optica is an inflammatory demyelinating disorder normally restricted to the optic nerves and spinal cord. Since the identification of a specific autoantibody directed against aquaporin 4, neuromyelitis optica-immunoglobulin G/aquaporin 4 antibody, neuromyelitis optica has been considered an entity
Edjah K Nduom et al.
Journal of neurosurgery, 119(2), 427-433 (2013-04-30)
The astrocytic contribution to the blood-brain barrier (BBB) in metastatic and primary malignant brain tumors is not well understood. To better understand the vascular properties associated with metastatic and primary malignant brain tumors, the authors systematically analyzed the astrocytic component
Stefanie Gurnik et al.
Acta neuropathologica, 131(5), 753-773 (2016-03-05)
The homeostasis of the central nervous system is maintained by the blood-brain barrier (BBB). Angiopoietins (Ang-1/Ang-2) act as antagonizing molecules to regulate angiogenesis, vascular stability, vascular permeability and lymphatic integrity. However, the precise role of angiopoietin/Tie2 signaling at the BBB
Christina Stefanitsch et al.
Frontiers in cellular neuroscience, 9, 456-456 (2015-12-10)
The serine protease tissue-type plasminogen activator (tPA) is used as a thrombolytic agent in the management of ischemic stroke, but concerns for hemorrhagic conversion greatly limits the number of patients that receive this treatment. It has been suggested that the
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