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GF172

Sigma-Aldrich

FGF-10 Protein, Human Recombinant, 25µg

The Fibroblast Growth Factors (FGFs) are heparin binding glycoproteins that exert a variety of biological activities toward cells of mesenchymal, neuronal & epithelial origin.

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Synonym(s):
FGF10, Fibroblast Growth Factor 10, Keratinocyte growth factor 2
eCl@ss:
32160405
NACRES:
NA.75

Quality Level

assay

>95% (SDS-PAGE and HPLC)

impurities

<0.1 μg/mg protein endotoxin (<1EU/μg)

UniProt accession no.

shipped in

dry ice

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GF321GF306GF307
Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

impurities

<0.1 μg/mg protein endotoxin (<1EU/μg)

impurities

<0.1 μg/mg protein endotoxin (<1 EU/μg)

impurities

<0.1 μg/mg protein endotoxin (<1EU/μg)

impurities

<0.1 μg/mg protein endotoxin (<1EU/μg)

UniProt accession no.

O15520

UniProt accession no.

P05230

UniProt accession no.

P05019

UniProt accession no.

P01138

General description

The Fibroblast Growth Factors (FGFs) are heparin binding glycoproteins that exert a variety of biological activities toward cells of mesenchymal, neuronal, and epithelial origin. FGF10 belongs to the subgroup of FGFs that also includes FGF3, 7, and 22. Proteins of this family play a central role during prenatal development and postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. FGF-10 is most related to KGF/FGF-7 and is expressed during the development and preferentially in adult lungs. It signals through the FGFR 2b. Recombinant human FGF-10 is a 19.3 kDa protein consisting of 170 amino acid residues.

Quality

Bioactivity assay #1: The ED50 as determined by the dose-dependent stimulation of thymidine uptake by BaF3 cells expressing FGF− receptors is = 0.5 ng/ml, corresponding to a specific activity of = 2 × 106 units/mg.
Bioactivity assay #2: Determined by a cell proliferation assay using 4MBr-5 cells. The expected−ED50−for this effect is 0.5−15.0 ng/ml.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1


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