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GF313

Sigma-Aldrich

TGF- α Protein, Human Recombinant Animal Free

Transforming growth factor alpha (TGF-α) is an EGF-related polypeptide growth factor that signals through the EGF receptor & stimulates the proliferation of a wide range of epidermal & epithelial cells. Manufactured using all non-animal reagents.

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Synonym(s):
Transforming growth factor alpha, TGFa, TGF alpha, EGF-like TGF, TGF type 1
eCl@ss:
32160405
NACRES:
NA.75

recombinant

expressed in E. coli

Quality Level

assay

>98% (SDS-PAGE and HPLC)

impurities

<0.1 μg/mg protein endotoxin (<1EU/μg)

NCBI accession no.

UniProt accession no.

shipped in

dry ice

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GF317GF176GF113
assay

>98% (SDS-PAGE and HPLC)

assay

>98% (SDS-PAGE and HPLC)

assay

>98% (SDS-PAGE and HPLC)

assay

>95% (SDS-PAGE)

impurities

<0.1 μg/mg protein endotoxin (<1EU/μg)

impurities

<0.1 μg/mg protein endotoxin (<1 EU/μg)

impurities

<0.1 μg/mg protein endotoxin (<1 EU/μg)

impurities

<0.1 ng/μg Endotoxin (of TGF-Beta2; 1EU/ug)

UniProt accession no.

P01135

UniProt accession no.

P10600

UniProt accession no.

P10600

UniProt accession no.

P61812

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

General description

Product Source: E. coli
Transforming growth factor alpha (TGF-α) is an EGF-related polypeptide growth factor that signals through the EGF receptor, and stimulates the proliferation of a wide range of epidermal and epithelial cells. It is produced by monocytes, keratinocytes, and various tumor cells. TGF-α induces transformation anchorage independence in cultured cells. Human, murine and rat TGF-α are cross-species reactive. Recombinant human TGF-α is a 50 amino acid polypeptide (5.5 kDa) which shares approximately 40% sequence homology with EGF, including 6 conserved cysteine residues, which form 3 intramolecular disulfide bonds.

Specificity

Cross Reactivty
Chicken, Mouse, Rat

Application

Research Category
Stem Cell Research
Research Sub Category
Growth Factors & Receptors

Quality

Bioactivity assay: Determined by its ability to stimulate the proliferation of mouse Balb/c 3T3 cells. The expected ED50 is ≤ 0.2 ng/ml, corresponding to a specific activity of ≥ 5 x 106 units/mg.

Physical form

Product is filtered through a 0.2 micron filter before lyophilization.
Recombinant animal free human TGF- α is manufactured using all non-animal reagents

Storage and Stability

Store at -20°C for up to 6 months from date of receipt.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable


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Henkel Valentine et al.
Cancer research communications, 2(11), 1355-1371 (2023-01-17)
Prostate cell lines from diverse backgrounds are important to addressing disparities in prostate cancer (PCa) incidence and mortality rates among Black men. ACRJ-PC28 was developed from a transrectal needle biopsy and established via inactivation of the CDKN2A locus and simultaneous

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