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HX0514

Sigma-Aldrich

Hyaluronidase

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Synonym(s):
Hyaluronidase
CAS Number:
MDL number:

conjugate

conjugate (Glucosaminoglycan)

Quality Level

form

powder

specific activity

≥300 units/mg dry wt.

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

white

shipped in

ambient

storage temp.

−20°C

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This Item
H2126H6254H3506
Hyaluronidase

HX0514

Hyaluronidase

Hyaluronidase from sheep testes Type II, lyophilized powder, ≥300 units/mg solid

H2126

Hyaluronidase from sheep testes

Hyaluronidase from sheep testes Type V, lyophilized powder, ≥1,500 units/mg solid

H6254

Hyaluronidase from sheep testes

Hyaluronidase from bovine testes Type I-S, lyophilized powder, 400-1000 units/mg solid

H3506

Hyaluronidase from bovine testes

form

powder

form

lyophilized powder

form

lyophilized powder

form

lyophilized powder

shipped in

ambient

shipped in

-

shipped in

-

shipped in

wet ice

storage condition

OK to freeze

storage condition

-

storage condition

-

storage condition

-

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

manufacturer/tradename

Calbiochem®

manufacturer/tradename

-

manufacturer/tradename

-

manufacturer/tradename

-

General description

300 units/mg minimum, 50,000 units/vial. Suitable for biochemistry grade.

Specifications:Activity: 300NF U/mg min





Intended for laboratory and manufacturing use only. Not for drug, food, or household use.

Application

Hyaluronidase has been used:
  • to enzymatically remove extra-cellular matrix (ECM) to assess the lateral diffusion of the synaptic a-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor (AMPAR)
  • to study the effects of 4-methylumbelliferone (4MU)/ hyaluronidase (HLX)-mediated depletion of the CD44/hyaluronan complex on trastuzumab binding in JIMT1 breast cancer xenografts
  • as a component of Hank′s balanced salt solution (HBSS) medium to digest fetal intestine tissue

Biochem/physiol Actions

Hyaluronidase is an endoglycosidase that degrades hyaluronic acid (HA), a component of the extracellular matrix. It is used to enhance drug diffusion and reverse the effects of HA filler injections. Hyaluronidases dissolve the subcutaneous nodules and can correct excessive quantities of injected filler. It eliminates the cumulus-corona-oocyte complex formed during intracytoplasmic sperm injection. Hyaluronidase inhibits tissue damage after the extravasation of several substances. It is used for reducing edema treating vitreous hemorrhage.

Unit Definition

One unit is based on the change in absorbency (turbidity) at 540 nm of an internal standard assayed concurrently with each lot. Internal standard replaces USP/NF reference no longer available.

Physical form

Dialyzed, lyophilized powder, not less than300 units per mg (dry weight).

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

Health hazard

signalword

Danger

hcodes

Hazard Classifications

Resp. Sens. 1

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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