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MABD123

Sigma-Aldrich

Anti-Osteocalcin Antibody, Clone 7D1.13

clone 7D1.13, from mouse

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Synonym(s):
Bone Gla protein, BGP, BGLAP, Gamma-carboxyglutamic acid-containing protein
eCl@ss:
32160702
NACRES:
NA.41

biological source

mouse

Quality Level

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

7D1.13, monoclonal

species reactivity

human

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
immunohistochemistry (frozen sections): suitable

isotype

IgG1κ

NCBI accession no.

UniProt accession no.

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... BGLAP(632)

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This Item
MABS1978AB1857MABS1989
species reactivity

human

species reactivity

human

species reactivity

human

species reactivity

human

Gene Information

human ... BGLAP(632)

Gene Information

human ... BGLAP(632)

Gene Information

human ... BGLAP(632)

Gene Information

human ... BGLAP(632)

antibody form

purified immunoglobulin

antibody form

purified immunoglobulin

antibody form

serum

antibody form

serum

clone

7D1.13, monoclonal

clone

5C5, monoclonal

clone

polyclonal

clone

4C5, monoclonal

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

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General description

Osteocalcin is an abundant, non-collagenous protein component of bone that is produced by osteoblasts. Osteocalcin appears transiently in embryonic bone at the time of mineral deposition, where it binds to hydroxyapatite in a calcium-dependent manner. In addition, osteocalcin is one of the most abundant, non-collagenous proteins found in mineralized adult bone. Osteocalcin is often studied in the osteogenesis of embryonic and mesenchymal stem cells.

Immunogen

KLH-conjugated linear peptide corresponding to Human Osteocalcin.

Application

Detect Osteocalcin using this mouse monoclonal antibody, Anti-Osteocalcin Antibody, Clone 7D1.13 validated for use in IHC (Paraffin) & IHC (tissue).
Research Sub Category
Mesenchymal Stem Cells

Osteobiology

Quality

Evaluated by Immunohistochemistry on human trabecular bone in a human bone biopsy.
Immunohistochemical Analysis: A 1:50 Dilution of this antibody detected osteocalcin on human trabecular bone in a human bone biopsy.

Target description

~6 kDa calculated

Linkage

Replaces: MABD182

Physical form

Format: Purified

Analysis Note

Control
Human trabecular bone in a human bone biopsy.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable


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Hao Cheng et al.
Acta biomaterialia, 69, 342-351 (2018-01-26)
The inorganic part of human bone is mainly composed of hydroxyapatite (HAP: Ca10(PO4)6(OH)2) and whitlockite (WH: Ca18Mg2(HPO4)2(PO4)12) minerals, where the WH phase occupies up to 20-35% of total weight. These two bone minerals have different crystal structures and physicochemical properties
Stylianos Kosmidis et al.
Cell reports, 25(4), 959-973 (2018-10-26)
Precisely deciphering the molecular mechanisms of age-related memory loss is crucial to create appropriate therapeutic interventions. We have previously shown that the histone-binding protein RbAp48/Rbbp4 is a molecular determinant of Age-Related Memory Loss. By exploring how this protein regulates the
Zhe Shi et al.
International journal of nanomedicine, 15, 9337-9353 (2020-12-03)
Autologous bone grafts are the gold standard for treating bone defects. However, limited bone supply and morbidity at the donor site restrict its extensive use. Therefore, developing bone graft materials as an alternative to autologous grafts has gained considerable attention.
Zhe Shi et al.
International journal of nanomedicine, 16, 5603-5619 (2021-08-26)
Given that autologous bone graft for bone defects is limited by insufficient supply and morbidity at the donor site, developing biomimetic graft materials as an alternative has gained consistent attention. However, obstacles in designing bone-mimetic materials that could integrate the

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