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32473

Supelco

Metoclopramide

VETRANAL®, analytical standard

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Synonym(s):
4-Amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxybenzamide, Methoxychloroprocainamide
Empirical Formula (Hill Notation):
C14H22ClN3O2
CAS Number:
Molecular Weight:
299.80
Beilstein/REAXYS Number:
1884366
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.24

grade

analytical standard

Quality Level

product line

VETRANAL®

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

CCN(CC)CCNC(=O)c1cc(Cl)c(N)cc1OC

InChI

1S/C14H22ClN3O2/c1-4-18(5-2)7-6-17-14(19)10-8-11(15)12(16)9-13(10)20-3/h8-9H,4-7,16H2,1-3H3,(H,17,19)

InChI key

TTWJBBZEZQICBI-UHFFFAOYSA-N

Gene Information

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This Item
M1824990PHR1132PHR2283
Metoclopramide VETRANAL®, analytical standard

32473

Metoclopramide

Metoclopramide European Pharmacopoeia (EP) Reference Standard

M1824990

Metoclopramide

Supelco

PHR1132

Metoclopramide Hydrochloride

Supelco

PHR2283

Metoclopramide Related Compound A

format

neat

format

neat

format

neat

format

-

product line

VETRANAL®

product line

-

product line

-

product line

-

shelf life

limited shelf life, expiry date on the label

shelf life

-

shelf life

-

shelf life

-

technique(s)

HPLC: suitable

technique(s)

-

technique(s)

-

technique(s)

-

application(s)

forensics and toxicology
pharmaceutical (small molecule)

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical (small molecule)

application(s)

-

General description

Metoclopramide is a drug, which can be effective in the treatment of severe nausea and vomiting caused by the anticancer drug cis-platinum.
Metoclopramide is typically employed as an antiemetic drug or a gastrointestinal prokinetic drug in adults and children.

Application

Metoclopramide may be used as a reference standard for the determination of the analyte in serum samples using reversed-phase high-performance liquid chromatography (RP-HPLC) with electrochemical detection.
Metoclopramide may be used as an analytical reference standard for the determination of the analyte in:
  • Human plasma by liquid–liquid extraction (LLE) with dichloromethane followed by hydrophilic interaction chromatography-electrospray iionization-tandem mass spectrometry (HILIC-ESI-MS/MS) operating in selected reaction monitoring (SRM) mode of detection.

It may also be used as an internal standard for the determination of loratadine and desloratadine in:
  • Human plasma by high performance liquid chromatography (HPLC) coupled to MS/MS with multiple reaction monitoring (MRM) detection.

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Legal Information

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

Exclamation mark

signalword

Warning

hcodes

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1


Certificates of Analysis (COA)

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Determination of loratadine and its active metabolite in human plasma by high-performance liquid chromatography with mass spectrometry detection.
Vlase L, et al.
Journal of Pharmaceutical and Biomedical Analysis, 44(3), 652-657 (2007)
David C Currow et al.
Journal of palliative medicine, 15(10), 1071-1075 (2012-08-01)
Understanding the performance of prescribed medications in day-to-day practice is important to minimize harm, maximize clinical benefits, and, eventually, better target the people who are most likely to benefit, especially in hospice/palliative care where there may be limited time to
RP?HPLC method with electrochemical detection for the determination of metoclopramide in serum and its use in pharmacokinetic studies.
Lamparczyk H, et al.
Biomedical Chromatography, 15(8), 513-517 (2001)
Double-blind crossover study of the antiemetic efficacy of high-dose dexamethasone versus high-dose metoclopramide.
Aapro SM, et al.
Journal of Clinical Oncology, 2(5), 466-471 (1984)
Metoclopramide: pharmacology and clinical application.
Albibi R and McCALLUM RW
Annals of Internal Medicine, 98(1), 86-95 (1983)

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