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59924

Sigma-Aldrich

Polysorbate 80

tested according to Ph. Eur.

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Synonym(s):
TWEEN® 80, Polysorbatum 80, POE (20) sorbitan monooleate, Polyethylene glycol sorbitan monooleate, Polyoxyethylenesorbitan monooleate, Polysorbate 80
CAS Number:
9005-65-6
MDL number:
MFCD00082107
NACRES:
NA.21

Agency

USP/NF
tested according to Ph. Eur.

Quality Level

200

vapor pressure

<1 mmHg ( 20 °C)

description

non-ionic

form

liquid

mol wt

average mol wt 79,000

aggregation number

60

refractive index

n20/D 1.472 (lit.)

CMC

0.012

transition temp

cloud point 65 °C

density

1.064 g/mL at 25 °C (lit.)

HLB

15

application(s)

pharmaceutical (small molecule)

InChI

1S/C32H60O10/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-30(36)40-25-24-37-27-29(39-22-19-34)32-28(38-21-18-33)26-31(42-32)41-23-20-35/h9-10,28-29,31-35H,2-8,11-27H2,1H3/b10-9+

InChI key

RGPBUVUVZKQNHD-MDZDMXLPSA-N

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This Item
W291706P6224P1754
Polysorbate 80 tested according to Ph. Eur.

Sigma-Aldrich

59924

Polysorbate 80

Polysorbate 80 FG

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W291706

Polysorbate 80

TWEEN&#174; 80 from non-animal source

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TWEEN® 80

TWEEN&#174; 80 viscous liquid

Sigma-Aldrich

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TWEEN® 80

form

liquid

form

-

form

viscous liquid

form

viscous liquid

mol wt

average mol wt 79,000

mol wt

-

mol wt

micellar avg mol wt 79,000, average mol wt 1310

mol wt

micellar avg mol wt 79,000, average mol wt 1310

aggregation number

60

aggregation number

-

aggregation number

60

aggregation number

60

CMC

0.012

CMC

-

CMC

0.012 mM (20-25°C)

CMC

0.012 mM (20-25°C)

transition temp

cloud point 65 °C

transition temp

-

transition temp

cloud point 65 °C

transition temp

cloud point 65 °C

General description

Polysorbate 80 is a surfactant. Polysorbates are a combination of oleic esters of sorbitol and sorbitanes with polyethylene glycol chains.

Application

Polysorbate 80 has been used in drug (rapamycin) treatment and to study the effect of rapamycin on osteolysis and tumor growth. It has also been used in the preparation of spray-dried emulsions and to study antibacterial efficacy.

Biochem/physiol Actions

Polysorbates is used as emulsifiers, dissolving agents and stabilizer for essential oils, topical application and medical infusions including intravenous, subcutaneous or intramuscular administration.

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Nilsel Okudan et al.
Brain research bulletin, 165, 81-89 (2020-10-04)
Statins are cholesterol lowering drugs that decrease the risk of cardiovascular events, but they are related with a few unfavorable symptoms in skeletal muscle including myopathy, and mild to moderate fatigue. Additionally, there has been discrepancies about the impacts of
Relationship between Polysorbate 80 solubilization descriptors and octanol-water partition coefficients of drugs
Alvarez Nunez FA and Yalkowsky SH
International Journal of Pharmaceutics, 200(2), 217-222 (2000)
Priya N O Kasimbeg et al.
Journal of pharmaceutical sciences, 108(1), 155-161 (2018-10-14)
Characterizing protein aggregates in the presence of silicone oil is a long standing challenge for the pharmaceutical industry. Silicone oil is often used as a lubricant in devices that deliver and store therapeutic protein products and has been linked to
Rapamycin inhibits osteolysis and improves survival in a model of experimental bone metastases
Hussein O, et al.
Cancer letters, 314(2), 176-184 (2012)
Osteolysis and pain due to experimental bone metastases are improved by treatment with rapamycin
Abdelaziz DM, et al.
Breast Cancer Research and Treatment, 143(2), 227-237 (2014)
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