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S6760

Sigma-Aldrich

Span® 80

nonionic surfactant

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Synonym(s):
Sorbitane monooleate, sorbitan oleate
CAS Number:
1338-43-8
EC Number:
215-665-4
MDL number:
MFCD00080948
PubChem Substance ID:
24899720
NACRES:
NA.25

Quality Level

200

mol wt

428.62 g/mol

concentration

≥60% (GC)

HLB

4.3

application(s)

microbiology

SMILES string

CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O

InChI

1S/C24H44O6/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-22(27)29-19-21(26)24-23(28)20(25)18-30-24/h9-10,20-21,23-26,28H,2-8,11-19H2,1H3/b10-9-/t20-,21+,23+,24+/m0/s1

InChI key

NWGKJDSIEKMTRX-AAZCQSIUSA-N

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This Item
855488.4012309569
Span® 80 nonionic surfactant

Sigma-Aldrich

S6760

Span® 80

Span® 80 viscosity 1000-2000 mPa.s (20 °C)

Supelco

85548

Span® 80

Span® 80 for synthesis

Sigma-Aldrich

8.40123

Span® 80

Span® 80 suitable for GC

Supelco

09569

Span® 80

HLB

4.3

HLB

-

HLB

-

HLB

-

application(s)

microbiology

application(s)

-

application(s)

-

application(s)

-

concentration

≥60% (GC)

concentration

-

concentration

-

concentration

-

General description

Span® 80 is a nonionic surfactant.

Application

Span® 80 has been used in a study to assess transfersomes as a transdermal delivery system for sertraline. It has also been used in a study to investigate the dominant factors affecting the stability of nanoemulsions through the use of artificial neural networks (ANNs).

Other Notes

Fatty acid composition: Oleic acid (C18:1) ≤ 60%; balance primarily linoleic (C18:2), linolenic (C18:3) and palmitic (C16:0) acids.

Legal Information

Span is a registered trademark of Croda International PLC

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Ankit Gupta et al.
Scientia pharmaceutica, 80(4), 1061-1080 (2012-12-25)
The aim of the present study was to investigate transfersomes as a transdermal delivery system for the poorly soluble drug, sertraline, in order to overcome the troubles associated with its oral delivery. Different transfersomal formulations were prepared with non-ionic surfactant
Jingchun Zhang et al.
Langmuir : the ACS journal of surfaces and colloids, 28(17), 6769-6775 (2012-04-06)
The effects of salt on emulsions containing sorbitan oleate (Span 80) and Laponite particles were investigated. Surprisingly, a novel double phase inversion was induced by simply changing the salt concentration. At fixed concentration of Laponite particles in the aqueous phase
Keita Hayashi et al.
International journal of biological sciences, 9(2), 142-148 (2013-02-16)
Span 80 (sorbitan monooleate) vesicles behaved differently from conventional phospholipid vesicles (liposomes) because the former had a more fluid interface. After doxorubicin hydrochloride (DOX) was encapsulated into the Span 80 vesicle (loading efficiency: 63 %), DOX-loaded Span 80 vesicles (DVs)
Keita Hayashi et al.
Colloids and surfaces. B, Biointerfaces, 106, 258-264 (2013-02-26)
We have focused on the interaction between the Span 80 vesicle and phospholipid vesicle (liposome). The Span 80 vesicle was mixed with a phospholipid vesicle (liposome), used as a simplified model of plasma membrane. From calcein leakage experiments, it was
Jean-François Cotte et al.
International journal of pharmaceutics, 436(1-2), 233-239 (2012-06-21)
Mass spectrometry (MS) and high performance liquid chromatography coupled to mass spectrometry (HPLC-MS) techniques were developed to characterize two surfactants, cetheareth-12 and sorbitan oleate, used to manufacture AF03, an emulsified oil-in-water (O/W) adjuvant. MS was first used to characterize the
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