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S7010

Sigma-Aldrich

Span® 60

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Synonym(s):
Sorbitan stearate, Sorbitane monostearate
CAS Number:
1338-41-6
EC Number:
215-664-9
MDL number:
MFCD00005366
UNSPSC Code:
12161900
PubChem Substance ID:
24899728
NACRES:
NA.25

description

non-ionic

Quality Level

200

mol wt

430.63 g/mol

concentration

45-55% (GC)

SMILES string

CCCCCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O

InChI

1S/C24H46O6/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-22(27)29-19-21(26)24-23(28)20(25)18-30-24/h20-21,23-26,28H,2-19H2,1H3/t20-,21?,23+,24+/m0/s1

InChI key

HVUMOYIDDBPOLL-XGKPLOKHSA-N

Related Categories

General description

Span® 60 is a sorbitan monoester than is used as a non-ionic detergent.

Application

Span® 60 has been used in a study to assess encapsulation of doxorubicin in niosomes as a route to tumor targeting. It has also been used in a study to investigate the use of nonionic surfactants as contrast agents for use in diagnostic ultrasounds.

Other Notes

Fatty acid composition: Stearic acid (C18:0) approx. 50%; balance primarily palmitic acid (C16:0).

Legal Information

Span is a registered trademark of Croda International PLC

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificates of Analysis (COA)

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Preparation and properties of vesicles (niosomes) of sorbitan monoesters ([TM="Span"] 20, 40, 60 and 80) and a sorbitan triester ([TM="Span"] 85).
Yoshioka, T., et al.
International Journal of Pharmaceutics, 105, 1-1 (1994)
I F Uchegbu et al.
Pharmaceutical research, 12(7), 1019-1024 (1995-07-01)
Encapsulation of doxorubicin in niosomes was sought as a route to tumour targeting and improved tumoricidal through the alteration of doxorubicin pharmacokinetics and metabolism. Doxorubicin niosomes (10 mg kg-1 doxorubicin) prepared from sorbitan monostearate (Span 60), cholesterol and choleth-24 (a
Surfactant-stabilized microbubbles as ultrasound contrast agents: stability study of [TM="Span"] 60 and Tween 80 mixtures using a Langmuir trough
Singhal, S., et al.
Langmuir, 9, 2426-2426 (1993)
Karimunnisa Sameer Shaikh et al.
Drug development and industrial pharmacy, 36(8), 946-953 (2010-03-04)
Niosomal delivery can prove an alternative to improve the poor skin penetration and residence of the topical antifungal drugs that account for the long treatment regimes in cutaneous mycosis. To investigate niosomes as carriers for dermal delivery of ciclopirox olamine
Yvette Meissner et al.
International journal of pharmaceutics, 335(1-2), 147-153 (2006-12-08)
Low molecular weight heparins (LMWH) have shown efficacy in the treatment of inflammatory bowel disease after parenteral administration however risking severe hemorrhagic adverse effects. Therefore, an oral colonic targeted heparin dosage form allowing the release of LMWH directly in the
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