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S7135

Sigma-Aldrich

Span® 85

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Synonym(s):
Sorbitane trioleate
CAS Number:
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.25

description

non-ionic

mol wt

957.52 g/mol

solubility

chloroform: 50 mg/mL, clear, faintly to light yellow

HLB

1.8

SMILES string

CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](O)C1OC[C@H](OC(=O)CCCCCCC\C=C/CCCCCCCC)[C@H]1OC(=O)CCCCCCC\C=C\CCCCCCCC

InChI

1S/C60H108O8/c1-4-7-10-13-16-19-22-25-28-31-34-37-40-43-46-49-56(62)65-52-54(61)59-60(68-58(64)51-48-45-42-39-36-33-30-27-24-21-18-15-12-9-6-3)55(53-66-59)67-57(63)50-47-44-41-38-35-32-29-26-23-20-17-14-11-8-5-2/h25-30,54-55,59-61H,4-24,31-53H2,1-3H3/b28-25-,29-26-,30-27+/t54-,55+,59-,60-/m1/s1

InChI key

ZBNRGEMZNWHCGA-WECPCUOASA-N

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1 of 4

This Item
855488.401248.40123
vibrant-m

S7135

Span® 85

vibrant-m

85548

Span® 80

vibrant-m

8.40124

Span® 85

vibrant-m

8.40123

Span® 80

mol wt

957.52 g/mol

mol wt

428.60 g/mol

mol wt

-

mol wt

-

HLB

1.8

HLB

-

HLB

-

HLB

-

solubility

chloroform: 50 mg/mL, clear, faintly to light yellow

solubility

-

solubility

insoluble <0.001 g/L

solubility

-

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

General description

Sorbitane trioleate, or Span 85, is a non-ionic detergent.

Application

Sorbitane trioleate, or Span 85, has been used in a study to develop a novel bottom-up process to produce nanoparticles containing protein and peptide for suspension in hydrofluoroalkane propellants. It has also been used in a study to analyze the application of liquid chromatography in polymer non-ionic antistatic additives.

Other Notes

Fatty acid composition: Oleic acid (C18:1) ≥ 60%; linoleic acid (C18:2) 3 - 12%; linolenic acid (C18:2) ≤ 3%; palmitoleic acid (C16:1) 2 - 6%; balance primarily palmitic acid (C16:0).

Legal Information

Span is a registered trademark of Croda International PLC

Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

437.0 °F

flash_point_c

225 °C

ppe

Eyeshields, Gloves, type ABEK (EN14387) respirator filter


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A novel bottom-up process to produce nanoparticles containing protein and peptide for suspension in hydrofluoroalkane propellants
Tan, Y., et al.
International Journal of Pharmaceutics, 413, 7-7 (2011)
M Victoria González-Rodríguez et al.
Journal of separation science, 33(22), 3595-3603 (2010-10-12)
This article investigates the applicability of HPLC-UV, ultra performance LC-evaporative light-scattering detection (UPLC-ELSD), HPLC-ESI(+)-MS and HPLC-hybrid linear ion trap (LTQ) Orbitrap MS for the analysis of different non-ionic antistatic additives, Span 20, Span 60, Span 65, Span 80, Span 85
Hiroaki Todo et al.
International journal of pharmaceutics, 271(1-2), 41-52 (2004-05-08)
The effect of pulmonary absorption enhancers on the stability of active ingredients is an important factor for successful inhalation therapy as well as the effect on pharmacological activity and safety. We examined the effect of pulmonary absorption enhancers on the
A N Hassan et al.
International journal of food microbiology, 87(1-2), 145-152 (2003-08-21)
The influence of surfactant hydrophobicity on detachment of Escherichia coli O157:H7 from lettuce was determined. Lettuce pieces inoculated with the pathogen were rinsed with Tween and Span surfactants of different hydrophobicity. Of the Tweens, only Tween 85, the Tween with
A C Singer et al.
Applied microbiology and biotechnology, 54(6), 838-843 (2001-01-11)
Partial bioremediation of polychlorinated biphenyl (PCB)-contaminated soil was achieved by repeated applications of PCB-degrading bacteria and a surfactant applied 34 times over an 18-week period. Two bacterial species, Arthrobacter sp. strain B1B and Ralstonia eutrophus H850, were induced for PCB

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