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α-Ketoglutaric acid

analytical standard

• Synonym(s): 2-Oxoglutaric acid, 2-Oxopentanedioic acid
• Linear Formula: HOOCCH₂CH₂COCOOH
• CAS Number: 328-50-7
• Molecular Weight: 146.10
• Beilstein/REAXYS Number: 1705689
• EC Number: 206-330-3
• MDL number: MFCD00004165
• UNSPSC Code: 41116107
• NACRES: NA.24

Properties

• grade: analytical standard
• assay: 99.0-101.0% (T)
• shelf life: limited shelf life, expiry date on the label
• application(s): clinical testing
• format: neat
• storage temp.: 2-8°C
• SMILES string: OC(=O)CCC(=O)C(O)=O
• InChI: 1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)
• InChI key: KPGXRSRHYNQIFN-UHFFFAOYSA-N

Description

General description

α-Ketoglutaric acid, an α-ketoacid, is identified as a potential, renal cell carcinoma (RCC) biomarker via urinary metabolomic profiling. It plays an important role in living beings as an angiogenesis suppressor.

Application

α-Ketoglutaric acid may be used as an analytical reference standard for the quantification of the analyte in the following:

• Human plasma samples using gas-chromatography coupled to mass spectrometry.
• Beer samples using high-performance liquid chromatography with UV detection, and further confirmed by high-performance liquid chromatography coupled to electrospray ionization tandem mass spectrometry (HPLC-ESI-MS/MS).
• Fruits and vegetables using HPLC-MS/MS.

Safety Information

• pictograms: GHS05
• signalword: Danger
• hcodes: H318
• pcodes: P280 - P305 + P351 + P338 + P310
• Hazard Classifications: Eye Dam. 1
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable