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76526

Supelco

L-Leucine

certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

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Synonym(s):
(S)-2-Amino-4-methylpentanoic acid
Linear Formula:
(CH3)2CHCH2CH(NH2)CO2H
CAS Number:
Molecular Weight:
131.17
Beilstein/REAXYS Number:
1721722
EC Number:
MDL number:
eCl@ss:
32160406
PubChem Substance ID:
E Number:
E641
NACRES:
NA.24

grade

certified reference material
TraceCERT®

Quality Level

product line

TraceCERT®

analyte chemical class(es)

amino acids, peptides, proteins

manufacturer/tradename

Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

color

white

mp

>300 °C (lit.)

application(s)

cleaning products
cosmetics
flavors and fragrances
food and beverages
personal care

format

neat

storage temp.

20-25°C

SMILES string

CC(C)C[C@H](N)C(O)=O

InChI

1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1

InChI key

ROHFNLRQFUQHCH-YFKPBYRVSA-N

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This Item
PHR1105W329703L8000
L-Leucine certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

76526

L-Leucine

-
L-Leucine Pharmaceutical Secondary Standard; Certified Reference Material

PHR1105

L-Leucine

-
L-Leucine 99%, FG

W329703

L-Leucine

-
L-Leucine reagent grade, ≥98% (HPLC)

L8000

L-Leucine

Essential Grade
technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

-

technique(s)

ligand binding assay: suitable

format

neat

format

neat

format

-

format

-

Quality Level

300

Quality Level

300

Quality Level

400

Quality Level

200

grade

certified reference material, TraceCERT®

grade

certified reference material, pharmaceutical secondary standard

grade

FG, Kosher

grade

reagent grade

storage temp.

20-25°C

storage temp.

2-8°C

storage temp.

-

storage temp.

-

General description

L-Leucine is an important and essential branched chain amino acid. It shows activity with the mechanistic target of rapamycin(mTOR) pathway, involved in the synthesis of proteins and satiety.
This certified reference material (CRM) is produced and certified in accordance with ISO/IEC 17025 and ISO 17034. This CRM is traceable to primary material from an NMI, e.g. NIST or NMIJ.
Certified content by quantitative NMR incl. uncertainty and expiry date are given on the certificate.
Download your certificate at: http://www.sigma-aldrich.com.

Check out the entire portfolio of our amino acids certified reference materials (CRM)

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Legal Information

TraceCERT is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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T1503
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25G
Pack Size/Quantity

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MMYOMAG-74K-13

1000309185

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Mullin.EG, et al. et al.
Integrative Weight Management: A Guide for Clinicians (2014)
Fleck M and Petrosyan.MA et al.
Salts of Amino Acids: Crystallization, Structure and Properties (2014)
Michael J Ormsby et al.
Cell reports, 30(7), 2297-2305 (2020-02-23)
Propionic acid (PA) is a bacterium-derived intestinal antimicrobial and immune modulator used widely in food production and agriculture. Passage of Crohn's disease-associated adherent-invasive Escherichia coli (AIEC) through a murine model, in which intestinal PA levels are increased to mimic the
Sebastian Kalamajski et al.
Matrix biology : journal of the International Society for Matrix Biology, 29(4), 248-253 (2010-01-19)
Small leucine-rich proteoglycans/proteins (SLRPs) are associated with collagen fibril formation, and therefore important for the proper formation of extracellular matrices. SLRPs are differentially expressed in tissues and during pathological conditions, contributing to the development of connective tissue properties. The binding
Qian Wang et al.
Journal of the National Cancer Institute, 105(19), 1463-1473 (2013-09-21)
L-type amino acid transporters (LATs) uptake neutral amino acids including L-leucine into cells, stimulating mammalian target of rapamycin complex 1 signaling and protein synthesis. LAT1 and LAT3 are overexpressed at different stages of prostate cancer, and they are responsible for

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