92732

Trimethylsulfonium hydroxide solution

~0.25 M in methanol, for GC derivatization, LiChropur^™

• Synonym(s): TMSH
• Linear Formula: (CH₃)₃S(OH)
• CAS Number: 17287-03-5
• Molecular Weight: 94.18
• Beilstein/REAXYS Number: 3910286
• MDL number: MFCD00216756
• UNSPSC Code: 12000000
• PubChem Substance ID: 329770161
• NACRES: NA.22

Properties

• grade: for GC derivatization
• Quality Level: 100
• form: liquid
• quality: LiChropur^™
• reaction suitability: reagent type: derivatization reagent; reaction type: Alkylations
• packaging: pkg of 10 × 1 mL
• concentration: ~0.25 M in methanol
• technique(s): gas chromatography (GC): suitable
• storage temp.: 2-8°C
• SMILES string: [OH-].C[S+](C)C
• InChI: 1S/C3H9S.H2O/c1-4(2)3;/h1-3H3;1H2/q+1;/p-1
• InChI key: MDTPTXSNPBAUHX-UHFFFAOYSA-M

Description

General description

Trimethylsulfonium hydroxide (TMSH) is a methylating reagent. It can be prepared by dissolving trimethylsulfonium iodide in methanol and water solvent further treating with silver oxide.

Application

TMSH solution has been used as a derivatizing agent in a study to determine the fatty acids in milk samples using thermochemolysis-gas chromatography-mass spectrometry.

Other Notes

Reagent for the methylation of nucleophiles, e.g. carboxylic acids, alcohols, thiols, N-heterocycles; Rapid derivatization of acids for GC by pre-column transesterification of glycerides

Legal Information

LiChropur is a trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• pictograms: GHS02,GHS06,GHS08
• signalword: Danger
• hcodes: H225,H301 + H311 + H331,H315,H319,H370
• pcodes: P210 - P280 - P301 + P310 - P303 + P361 + P353 - P304 + P340 + P311 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Eye Irrit. 2 - Flam. Liq. 2 - Skin Irrit. 2 - STOT SE 1
• target_organs: Eyes,Central nervous system
• Storage Class: 3 - Flammable liquids
• wgk_germany: WGK 2
• flash_point_f: 51.8 °F - closed cup
• flash_point_c: 11 °C - closed cup
• ppe: Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter