M8277

Midodrine hydrochloride

analytical standard, for drug analysis

• Synonym(s): (±)-1-(2,5-Dimethoxyphenyl)-2-glycinamidoethanol
• Empirical Formula (Hill Notation): C₁₂H₁₈N₂O₄ · HCl
• CAS Number: 3092-17-9
• Molecular Weight: 290.74
• NACRES: NA.24
• PubChem Substance ID: 329818055
• UNSPSC Code: 41116107
• MDL number: MFCD00079455

Properties

• Quality Segment: 100
• technique(s): HPLC: suitable, gas chromatography (GC): suitable
• application(s): forensics and toxicology; pharmaceutical (small molecule); veterinary
• format: neat
• SMILES string: Cl.COc1ccc(OC)c(c1)C(O)CNC(=O)CN
• InChI: 1S/C12H18N2O4.ClH/c1-17-8-3-4-11(18-2)9(5-8)10(15)7-14-12(16)6-13;/h3-5,10,15H,6-7,13H2,1-2H3,(H,14,16);1H
• InChI key: MGCQZNBCJBRZDT-UHFFFAOYSA-N
• Gene Information: human ... ADRA1A(148), ADRA1B(147), ADRA1D(146)

Description

General description

Midodrine is a prodrug and a long acting α-adrenergic stimulating agent, and forms an active metabolite, desglymidodrine, which causes an elevation of the systemic blood pressure with the reduction in heart rate.

Application

Midodrine hydrochloride may be used as an analytical reference standard for the quantification of the analyte in biological samples and pharmaceutical formulations using different chromatography techniques.

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

α-Adrenergic agonist; vasoconstrictor

Safety Information

• ppe: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
• pictograms: GHS06
• signalword: Danger
• hcodes: H301
• pcodes: P301 + P310
• Hazard Classifications: Acute Tox. 3 Oral
• Storage Class: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable