MilliporeSigma
All Photos(1)

Documents

P4347

Sigma-Aldrich

Propylene Glycol

meets USP testing specifications

Sign Into View Organizational & Contract Pricing

Synonym(s):
1,2-Propanediol, 1,2-PDO, Methylethyl glycol, Propane-1,2-diol, Propylene glycol
Linear Formula:
CH3CH(OH)CH2OH
CAS Number:
Molecular Weight:
76.09
Beilstein:
1340498
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.25

Agency

USP/NF
meets USP testing specifications

Quality Level

vapor density

2.62 (vs air)

vapor pressure

0.08 mmHg ( 20 °C)

autoignition temp.

779 °F

expl. lim.

12.5 %

refractive index

n20/D 1.432 (lit.)

bp

187 °C (lit.)

mp

−60 °C (lit.)

density

1.036 g/mL at 25 °C (lit.)

application(s)

pharmaceutical (small molecule)

SMILES string

CC(O)CO

InChI

1S/C3H8O2/c1-3(5)2-4/h3-5H,2H2,1H3

InChI key

DNIAPMSPPWPWGF-UHFFFAOYSA-N

Looking for similar products? Visit Product Comparison Guide

Compare Similar Items

View Full Comparison

Show Differences

1 of 4

This Item
16033PHR10511576708
Propylene Glycol meets USP testing specifications

Sigma-Aldrich

P4347

Propylene Glycol

1,2-Propanediol meets analytical specification of Ph. Eur., BP, USP, ≥99.5%

Sigma-Aldrich

16033

1,2-Propanediol

Propylene glycol Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1051

Propylene glycol

Propylene glycol United States Pharmacopeia (USP) Reference Standard

USP

1576708

Propylene glycol

vapor pressure

0.08 mmHg ( 20 °C)

vapor pressure

0.08 mmHg ( 20 °C)

vapor pressure

0.08 mmHg ( 20 °C)

vapor pressure

0.08 mmHg ( 20 °C)

autoignition temp.

779 °F

autoignition temp.

779 °F

autoignition temp.

779 °F

autoignition temp.

779 °F

expl. lim.

12.5 %

expl. lim.

12.5 %

expl. lim.

12.5 %

expl. lim.

12.5 %

refractive index

n20/D 1.432 (lit.)

refractive index

n20/D 1.431-1.433, n20/D 1.432 (lit.)

refractive index

n20/D 1.432 (lit.)

refractive index

n20/D 1.432 (lit.)

bp

187 °C (lit.)

bp

187 °C (lit.)

bp

187 °C (lit.)

bp

187 °C (lit.)

General description

Propylene glycol, a low-molecular-weight aliphatic alcohol, holds significance as a key solvent in biological and pharmaceutical formulation research. Its outstanding miscibility with water and diverse organic compounds, coupled with its low freezing point, low vapor pressure, and non-toxic nature, positions it as a preferred choice for a variety of research applications, particularly in sensitive biological assays and pharmaceutical preparations.

Going beyond its solvent capabilities, propylene glycol excels as an excipient in pharmaceutical formulations, enhancing the solubility and stability of therapeutic molecules and pharmaceutical additives. This attribute proves indispensable in excipient and drug delivery research, contributing to the development of more efficacious and stable medications. In biochemical and physiological research, propylene glycol functions as a potent cryoprotectant, safeguarding cells and tissues from freezing-induced damage. Its application extends to investigations of drug absorption, metabolism, and distribution, providing researchers with a crucial tool to decipher the intricate journey of drugs within the body.

The versatility of propylene glycol extends to molecular biology, particularly in Polymerase Chain Reaction (PCR), where it safeguards DNA and RNA strands, ensuring reliable and reproducible results. Studies demonstrate its exceptional ability to stabilize DNA for extended periods, making it an essential component for long-term sample preservation in genetic and genomic analyses. In the pharmaceutical industry, propylene glycol finds extensive use as a solvent and extraction medium, playing a pivotal role in drug development research, facilitating efficient extraction and purification of bioactive compounds.

Application

Propylene glycol has been used:
  • for removing excess Oil Red O stain in zebrafish larvae
  • in the preparation of alginate hydrogels
  • for the dissolution of androstenone
  • for the calibration of cone beam scanner in computed tomography

Features and Benefits

  • Versatile and adaptable for a wide variety of laboratory and research applications
  • Meets USP testing specifications

comparable product

Product No.
Description
Pricing

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

219.2 °F - closed cup

Flash Point(C)

104 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Documents related to the products that you have purchased in the past have been gathered in the Document Library for your convenience.

Visit the Document Library

Difficulty Finding Your Product Or Lot/Batch Number?

Product numbers are combined with Pack Sizes/Quantity when displayed on the website (example: T1503-25G). Please make sure you enter ONLY the product number in the Product Number field (example: T1503).

Example:

T1503
Product Number
-
25G
Pack Size/Quantity

Additional examples:

705578-5MG-PW

PL860-CGA/SHF-1EA

MMYOMAG-74K-13

1000309185

enter as 1.000309185)

Having trouble? Feel free to contact Technical Service for assistance.

Lot and Batch Numbers can be found on a product's label following the words 'Lot' or 'Batch'.

Aldrich Products

  • For a lot number such as TO09019TO, enter it as 09019TO (without the first two letters 'TO').

  • For a lot number with a filling-code such as 05427ES-021, enter it as 05427ES (without the filling-code '-021').

  • For a lot number with a filling-code such as STBB0728K9, enter it as STBB0728 without the filling-code 'K9'.

Not Finding What You Are Looking For?

In some cases, a COA may not be available online. If your search was unable to find the COA you can request one.

Request COA

Customers Also Viewed

Slide 1 of 8

1 of 8

1,2-Propanediol EMPLURA®

Supelco

8.22324

1,2-Propanediol

1,2-Propanediol EMPROVE® EXPERT, Ph. Eur., BP, USP

SAFC

1.07478

1,2-Propanediol

1,2-Propanediol analytical standard

Supelco

12279

1,2-Propanediol

Ethylene glycol anhydrous, 99.8%

Sigma-Aldrich

324558

Ethylene glycol

Glycerin meets USP testing specifications

Sigma-Aldrich

G2289

Glycerin

Polypropylene glycol P 400

Sigma-Aldrich

81350

Polypropylene glycol

S(−)-Nicotine solution 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

Supelco

N-008

S(−)-Nicotine solution

Wei-Chia Tseng et al.
Disease models & mechanisms, 11(9) (2018-08-24)
Niemann-Pick disease type C1 (NPC1) is a rare autosomal recessive lysosomal storage disease primarily caused by mutations in NPC1 NPC1 is characterized by abnormal accumulation of unesterified cholesterol and glycolipids in late endosomes and lysosomes. Common signs include neonatal jaundice
Li-Hao Huang et al.
Cell metabolism, 29(2), 475-487 (2018-11-13)
Lipoproteins trapped in arteries drive atherosclerosis. Extravascular low-density lipoprotein undergoes receptor uptake, whereas high-density lipoprotein (HDL) interacts with cells to acquire cholesterol and then recirculates to plasma. We developed photoactivatable apoA-I to understand how HDL passage through tissue is regulated.
Shawn C Chafe et al.
Cancer immunology research, 7(7), 1064-1078 (2019-05-16)
Treatment strategies involving immune-checkpoint blockade (ICB) have significantly improved survival for a subset of patients across a broad spectrum of advanced solid cancers. Despite this, considerable room for improving response rates remains. The tumor microenvironment (TME) is a hurdle to
Burak Altun et al.
Ultrasonics, 110, 106274-106274 (2020-11-02)
Tissue-mimicking materials (TMMs) play a key role in the quality assurance of ultrasound diagnostic equipment and should have acoustic properties similar to human tissues. We propose a method to quantify the acoustic properties of TMM samples through the use of
Gai Ling Li et al.
Journal of controlled release : official journal of the Controlled Release Society, 84(1-2), 49-57 (2002-10-26)
To achieve a therapeutical effect of the anti-Parkinson's drug R-apomorphine via iontophoresis delivery, enhancement strategies in vitro were explored using three structurally related enhancers, lauric acid (LA), dodecyltrimethylammonium bromide (DTAB) and Laureth-3 oxyethylene ether (C(12)EO(3)). Human stratum corneum and shed

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service