PHR1939
Hydroxyproline
Pharmaceutical Secondary Standard; Certified Reference Material
Synonym(s):
trans-4-Hydroxy-L-proline, (2S,4R)-4-Hydroxypyrrolidine-2-carboxylic acid, Hyp
About This Item
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grade
certified reference material
pharmaceutical secondary standard
Quality Level
API family
proline
CofA
current certificate can be downloaded
packaging
pkg of 500 mg
mp
273 °C (dec.) (lit.)
application(s)
pharmaceutical
format
neat
storage temp.
2-30°C
SMILES string
O[C@H]1CN[C@@H](C1)C(O)=O
InChI
1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4+/m1/s1
InChI key
PMMYEEVYMWASQN-DMTCNVIQSA-N
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General description
Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Hydroxyproline, found exclusively in collagen, is formed from the hydroxylation of proline. It is used as a biomarker to measure the collagen content of various biological samples.
Application
- Multi-analysis of acetylcarnitine, proline, hydroxyproline, citrulline, and arginine as possible biomarkers by liquid chromatography-tandem mass spectrometry (LC-MS/MS) in human plasma samples
- Simultaneous determination of proline and hydroxyproline in plasma samples by (LC-MS/MS using a new fluorescent reagent for pre-column derivatization
- Development of a micellar electrokinetic chromatography (MEKC) method to measure hydroxyproline in various dairy products upon in-capillary derivatization
- Quantitative analysis of free prolyl dipeptides, proline, and hydroxyproline by flow-gated capillary electrophoresis combined with laser-induced fluorescence detector from unhydrolyzed urine samples
Other Notes
Analysis Note
Footnote
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