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viscous liquid

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TWEEN® 80, POE (20) sorbitan monooleate, Polyethylene glycol sorbitan monooleate, Polyoxyethylenesorbitan monooleate, Polysorbate 80
CAS Number:
MDL number:



Quality Level


viscous liquid

mol wt

micellar avg mol wt 79.000
average mol wt 1310


Oleic acid, ≥58.0% (balance primarily linoleic, palmitic, and stearic acids)

greener alternative product characteristics

Use of Renewable Feedstocks
Design for Degradation
Learn more about the Principles of Green Chemistry.


0.012 mM (20-25°C)

transition temp

cloud point 65 °C


1.064 g/cm3



greener alternative category



InChI key


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General description

ECO Tween® 80, also known as Polyoxyethylenesorbitan monooleate, is a bio-based, nonionic detergent manufactured from a natural fatty acid. This surfactant, derived from natural sources, provides various functional advantages, such as detergency, emulsification, and wetting. Its versatility makes it well-suited for a variety of applications in biochemical and biological research, with common uses including cell lysis, protein extraction, nuclei isolation and cell fractionation.
We are committed to bringing you Greener Alternative Products, which adhere to one or more of The 12 Principles of Green Chemistry. This product is a biobased surfactant and is aligned with the 7th principle of Green Chemistry "Use of Renewable Feedstocks" and the 10th principle "Design for Degradation".


Non-ionic detergent used for selective protein extraction and isolation of nuclei from mammalian cell lines.
TWEEN® 80 has been used in drug vehicle solution for specific injections in mice and rats. It has been used for the determination of esterase activity in bacterial cells.

Biochem/physiol Actions

TWEEN® 80 is a polysorbate surfactant which helps in stabilizing proteins and in protein membrane studies. It is regularly used for the extraction of membrane proteins and isolation of nuclei from cells.

Features and Benefits

  • 100 % Renewable
  • 100 % Bio-based
  • Certified to the USDA BioPreferred Program
  • Lower carbon footprint than petrochemical-based versions
  • High-purity chemical suitable for a wide variety of research applications

Legal Information

ECO TWEEN is a registered trademark of Croda Inc.
TWEEN is a registered trademark of Croda International PLC

Storage Class Code

10 - Combustible liquids



Flash Point(F)

235.4 °F - closed cup

Flash Point(C)

> 113 °C - closed cup

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Pathogenic factors of Pseudomonas cepacia isolates from patients with cystic fibrosis.
Gessner AR and Mortensen JE
Journal of Medical Microbiology, 33, 115-115 (1990)
HU-210 shows higher efficacy and potency than morphine after intrathecal administration in the mouse formalin test.
Guhring H et al.
European Journal of Pharmacology, 429, 127-127 (2001)
Handbook of Biochemistry and Molecular Biology (2010)
V Ryu et al.
Neuroscience, 167(4), 1227-1238 (2010-03-04)
Previous reports show that vagal afferent innervation of the stomach eventually regenerates from surviving nodose ganglion (NG) neurons after subdiaphragmatic vagotomy. Systemic capsaicin treatment destroys gastric vagal afferent neurons expressing vanilloid receptor 1 (VR1). However, it is not known whether
Scopes RK
Protein Purification: Principles and Practice (1993)

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