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TWEEN® 85, Polyoxyethylenesorbitan Trioleate
CAS Number:
MDL number:



Quality Level


viscous liquid


Oleic acid, ≥50.0% (balance primarily C10-C18 fatty acids)

greener alternative product characteristics

Use of Renewable Feedstocks
Design for Degradation
Learn more about the Principles of Green Chemistry.


≥50% (GC)


4.8-5.2% water

acid number

≤2.0 mg KOH/g

hydroxyl value

39‑52 mg KOH/g



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General description

ECO TWEEN® 85, also known as Polyoxyethylene sorbitan trioleate, is a bio-based, nonionic detergent manufactured from a natural fatty acid. This surfactant, derived from natural sources, provides various functional advantages, such as detergency, emulsification, and wetting. Its versatility makes it well-suited for a variety of applications in biochemical and biological research, with common uses including cell lysis, protein extraction, nuclei isolation and cell fractionation.
We are committed to bringing you Greener Alternative Products, which adhere to one or more of The 12 Principles of Green Chemistry. This product is a biobased surfactant and is aligned with the 7th principle of Green Chemistry "Use of Renewable Feedstocks" and the 10th principle "Design for Degradation".


TWEEN 85 has been used in a study to assess the potential application of niosomes for the delivery of ammonium glycyrrhizinate for the treatment of inflammatory diseases. It has also been used in a study to investigate the joint-action of antifouling substances in copper-free paints.

Features and Benefits

  • 100 % Renewable
  • 100 % Bio-based
  • Certified to the USDA BioPreferred Program
  • Lower carbon footprint than petrochemical-based versions
  • High-purity chemical suitable for a wide variety of research applications

Legal Information

ECO TWEEN is a registered trademark of Croda Inc.
TWEEN is a registered trademark of Croda International PLC

Storage Class Code

10 - Combustible liquids



Flash Point(F)

300.2 °F - DIN 51758

Flash Point(C)

> 149 °C - DIN 51758

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Anti-inflammatory activity of novel ammonium glycyrrhizinate/ niosomes delivery system: Human and murine models
Marianecci, C., et al.
J. Controlled Release, 164, 17-17 (2012)
Fabienne Faÿ et al.
Colloids and surfaces. B, Biointerfaces, 102, 569-577 (2012-10-30)
Due to the environmentally harmful impact of tributyltin self-polishing paints, there is a critical need of more ecological alternatives. The aim of the present work is to study the joint-action of three molecules chosen in order to combine the two
Enzymatic activity of Chromobacterium viscosum lipase in an AOT/Tween 85 mixed reverse micellar system
Hossain, J., et al.
Journal of Chemical Technology and Biotechnology, 74, 423-423 (1999)
Rafaela C Sartore et al.
PloS one, 6(6), e20667-e20667 (2011-06-16)
The existence of loss and gain of chromosomes, known as aneuploidy, has been previously described within the central nervous system. During development, at least one-third of neural progenitor cells (NPCs) are aneuploid. Notably, aneuploid NPCs may survive and functionally integrate

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