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Sigma-Aldrich

Methoxypolyethylene glycol 5,000 propionic acid

≥80%

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Synonym(s):
Polyethylene glycol, O-(2-Carboxyethyl)-O′-methylpolyethylene glycol 5,000, mono-Methyl polyethylene glycol 5′000 propionic acid
MDL number:
NACRES:
NA.25

Quality Level

assay

≥80%

form

lumps

Ω-end

carboxylic acid

α-end

methoxy

storage temp.

−20°C

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This Item
8596970718920401
form

lumps

form

solid

form

powder

form

solid

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

Ω-end

carboxylic acid

Ω-end

-

Ω-end

carboxylic acid

Ω-end

(Propionic acid)

α-end

methoxy

α-end

-

α-end

methoxy

α-end

methoxy

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

2-8°C

Application

Methoxypolyethylene glycol 5,000 propionic acid (M-SPA-PEG 5000) is a pegylation agent used to conjugate proteins to reduce immunogenicity and prolong serum half-life of proteins and enzymes.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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Yihong Huang et al.
International journal of hematology, 92(4), 609-616 (2010-10-19)
We designed to determine whether pretreatment of allografts with methoxypolyethylene glycol-succinimidyl-propionic acid ester (mPEG-SPA) and an anti-OX40L monoclonal antibody (McAb) can relieve acute graft-versus-host disease in allogeneic bone marrow transplantation recipients. Responder splenocytes from C57BL/6 donor mice were incubated with
Y Tan et al.
Protein expression and purification, 12(1), 45-52 (1998-03-14)
Recombinant methioninase (rMETase) is a homotetrameric pyridoxal 5'-phosphate enzyme of 172-kda molecular mass derived from Pseudomonas putida and cloned in Escherichia coli. rMETase has been found previously to be an effective, anti-tumor agent in vitro and in vivo. The enzyme
Amanda J Bradley et al.
Biochimica et biophysica acta, 1561(2), 147-158 (2002-05-09)
Immunocamouflaged red blood cells (RBC) are produced by cell surface derivatization with methoxypolyethylene glycol (mPEG). These immunologically attenuated cells may reduce the risk of allosensitization in chronically transfused patients. To characterize the effects of differing linker chemistries and polymer lengths
Chun Zhang et al.
PloS one, 7(6), e39659-e39659 (2012-06-30)
Uricase has proven therapeutic value in treating hyperuricemia but sufficient reduction of its immunogenicity may be the largest obstacle to its chronic use. In this study, canine uricase was modified with 5 kDa mPEG-SPA and the impact of large aggregated

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