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A1520

Sigma-Aldrich

α-Amylase Inhibitor from Triticum aestivum (wheat seed)

Type I, lyophilized powder

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MDL number:
NACRES:
NA.77

biological source

Triticum estivum

Quality Level

type

Type I

form

lyophilized powder

specific activity

≥1000 inhibitor U/mg protein (using human salivary α-amylase)
≥200 inhibitor U/mg protein (using porcine pancreatic α-amylase)

composition

Protein, 35-65% biuret

storage temp.

−20°C

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This Item
A3176L9640A8220
vibrant-m

A3176

α-Amylase from porcine pancreas

vibrant-m

A8220

α-Amylase from Aspergillus oryzae

Quality Level

200

Quality Level

200

Quality Level

300

Quality Level

200

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

form

lyophilized powder

form

powder

form

lyophilized powder

form

aqueous solution

type

Type I

type

Type VI-B

type

-

type

-

specific activity

≥1000 inhibitor U/mg protein (using human salivary α-amylase)

specific activity

≥5 units/mg solid

specific activity

-

specific activity

≥800 FAU/g

General description

α-Amylases are endoglycosidases, that are classified into glycosyl hydrolase family 13 (1-3).

application

α-Amylase Inhibitor from Triticum aestivum (wheat seed) has been used to determine its effects on salivary gland (SG) amylase activity. It has also been used to inhibit the activity from the extract from Bemisia tabaci.

Biochem/physiol Actions

α-Amylases can hydrolyze α-(1,4)-D-glycosidic linkages. It participates in the breakdown of starch and glycogen. Inhibiting this enzyme can be used as a strategy to treat dental caries, diabetes, obesity and periodontal diseases.
Competitive inhibitor of human salivary α-amylase. KI = 2.9 nM, compared to a KM of 5.9 mM (calculated per mole of α-1,4-linked maltose residues).

Unit Definition

One unit will reduce the activity of two units of α-amylase (A0521) by 50% after pre-incubation at 25 °C.

Physical form

Lyophilized powder containing buffer salts as sodium phosphate.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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