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A2093

Sigma-Aldrich

Aspirin

meets USP testing specifications

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Synonym(s):
Acetylsalicylic acid, 2-Acetoxybenzoic acid, O-Acetylsalicylic acid, ASA, Aspirin
Linear Formula:
2-(CH3CO2)C6H4CO2H
CAS Number:
Molecular Weight:
180.16
Beilstein:
779271
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.21

Agency

USP/NF
meets USP testing specifications

Quality Level

form

powder or crystals

mp

134-136 °C (lit.)

application(s)

pharmaceutical (small molecule)

SMILES string

CC(=O)Oc1ccccc1C(O)=O

InChI

1S/C9H8O4/c1-6(10)13-8-5-3-2-4-7(8)9(11)12/h2-5H,1H3,(H,11,12)

InChI key

BSYNRYMUTXBXSQ-UHFFFAOYSA-N

Gene Information

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This Item
A5376A3160PHR1003
Aspirin meets USP testing specifications

Sigma-Aldrich

A2093

Aspirin

Acetylsalicylic acid ≥99.0%

Sigma-Aldrich

A5376

Acetylsalicylic acid

Acetylsalicylic acid analytical standard

Sigma-Aldrich

A3160

Acetylsalicylic acid

mp

134-136 °C (lit.)

mp

134-136 °C (lit.)

mp

134-136 °C (lit.)

mp

134-136 °C (lit.)

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

300

Gene Information

human ... ITGA2B(3674), PTGS1(5742), PTGS2(5743)

Gene Information

human ... ITGA2B(3674), ITGB3(3690), PTGS1(5742), PTGS2(5743)

Gene Information

human ... ITGA2B(3674), PTGS1(5742), PTGS2(5743)

Gene Information

human ... PTGS1(5742), PTGS2(5743)

agency

USP/NF

agency

-

agency

-

agency

traceable to BP 617, traceable to Ph. Eur. A0200000, traceable to USP 1044006

application(s)

pharmaceutical (small molecule)

application(s)

-

application(s)

forensics and toxicology
pharmaceutical
veterinary

application(s)

pharmaceutical (small molecule)

General description

Aspirin (acetylsalicylic acid) is a nonsteroidal anti-inflammatory drug. It occurs as white crystalline powder and is derived from salicylic acid.

Application

Aspirin has been used:
  • as a stabilizer for blood during 13,14-dihydro-15-keto-prostaglandin F2α (PGFM) measurement
  • to evaluate cell viability of BV-2 microglial cell line
  • in morphogenesis assay

Biochem/physiol Actions

Aspirin is an analgesic and antipyretic agent used in the treatment of fever and pain as in arthritis. It is also associated with cardiovascular diseases.
Blocks the production of prostaglandins by inhibiting cyclooxygenase (prostaglandin H synthase), with greater selectivity toward the COX-1 isoform. The antithrombotic effect is due to the inhibition of COX-1 in platelets that blocks thromboxane production and platelet aggregation. Chemopreventive against colorectal and other solid tumors.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Precautionary Statements

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

482.0 °F

Flash Point(C)

250 °C

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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USP

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Lactose (anhydrous)

Relationship between endotoxin and prostaglandin (PGE2 and PGFM) concentrations and ovarian function in dairy cows with puerperal endometritis
Mateus L, et al.
Animal Reproduction Science (2003)
The 100 Most Important Chemical Compounds: A Reference Guide (2011)
Acetylsalicylic acid enhances the anti-inflammatory effect of fluoxetine through inhibition of NF-kB, p38-MAPK and ERK1/2 activation in lipopolysaccharide-induced BV-2 microglia cells
Yang JM, et al.
Neuroscience, 275, 296-394 (2014)
Concise Clinical Pharmacology (2007)
Henry's Clinical Diagnosis and Management by Laboratory Methods E-book (2011)

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