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1005706

USP

Glacial acetic acid

United States Pharmacopeia (USP) Reference Standard

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Synonym(s):
Acetic acid, Ethanoic acid, Methanecarboxylic acid, Glacial acetic acid
Linear Formula:
CH3CO2H
CAS Number:
Molecular Weight:
60.05
Beilstein:
506007
MDL number:
PubChem Substance ID:
NACRES:
NA.24

grade

pharmaceutical primary standard

vapor density

2.07 (vs air)

API family

glacial acetic acid

autoignition temp.

800 °F

expl. lim.

16 %, 92 °F
4 %, 59 °F

manufacturer/tradename

USP

technique(s)

gas chromatography (GC): suitable

refractive index

n20/D 1.371 (lit.)

bp

117-118 °C (lit.)

mp

16.2 °C (lit.)

density

1.049 g/mL at 25 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

CC(O)=O

InChI

1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)

Inchi Key

QTBSBXVTEAMEQO-UHFFFAOYSA-N

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1 of 4

This Item
PHR17481.00056137130
Glacial acetic acid United States Pharmacopeia (USP) Reference Standard

USP

1005706

Glacial acetic acid

Glacial Acetic Acid Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1748

Glacial Acetic Acid

Acetic acid (glacial) 100%, EMPROVE® EXPERT, Ph. Eur., BP, JP, USP, E 260

SAFC

1.00056

Acetic acid

Acetic acid, glacial EMPROVE® EXPERT, Ph. Eur., JP, USP

SAFC

137130

Acetic acid, glacial

manufacturer/tradename

USP

manufacturer/tradename

-

manufacturer/tradename

-

manufacturer/tradename

-

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical (small molecule)

application(s)

liquid formulation
pharmaceutical
semi-solid formulation

application(s)

-

format

neat

format

neat

format

-

format

-

vapor density

2.07 (vs air)

vapor density

2.07 (vs air)

vapor density

2.07 (vs air)

vapor density

2.07 (vs air)

API family

glacial acetic acid

API family

glacial acetic acid

API family

-

API family

-

General description

Glacial acetic acid is the trivial name used to describe pure acetic acid in an anhydrous state. It is a clear and hygroscopic weak acid, typically available in concentrations ranging from 99.5% to 100%. The name "glacial" refers to the ice-like crystals that form at a temperature slightly below room temperature (16.6°C or 61.9°F), like the German term "Eisessig" (ice-vinegar). Despite being classified as a weak acid, glacial acetic acid is a corrosive poison that can cause harm or even be fatal when in contact with human tissue. Improper storage and handling of glacial acetic acid can pose inherent risks and may lead to patient injuries if not appropriately diluted. Acetic acid/acetate is a common counter ion in peptide preparations.
Glacial acetic acid USP reference standard is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Glacial acetic acid USP reference standard for use in specified quality tests and assays. It is also used to prepare standard solution by using liquid chromatography coupled to a UV detector according to the general chapter of United States Pharmacopeia (USP). Based directly on official monographs published in the USP-NF, these highly characterized physical specimens are used in testing by pharmaceutical and related industries to help ensure the identity, strength, quality, and purity of peptide-based medicines.
Further information is available in the general chapter, ?503? ACETIC ACID IN PEPTIDES, USP43-NF38 - 6741 of the USP (United States Pharmacopeia).
Glacial acetic acid USP reference standard for use in specified quality tests and assays.

Also used to prepare standard solution by using liquid chromatography coupled to a UV detector according to the monograph of United States Pharmacopeia (USP).

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

This product is intended for use as a reference standard in pharmaceutical research and development. It is not tested for animal or human consumption, clinical testing, or therapeutic use.
Sales restrictions may apply.

related product

Pictograms

FlameCorrosion

Signal Word

Danger

Hazard Statements

Hazard Classifications

Eye Dam. 1 - Flam. Liq. 3 - Skin Corr. 1A

Storage Class Code

3 - Flammable liquids

WGK

WGK 1

Flash Point(F)

102.2 °F

Flash Point(C)

39 °C


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Sigma-Aldrich

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Acetic acid glacial, ≥99.99% trace metals basis

Sigma-Aldrich

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ACETIC ACID IN PEPTIDES
USP43-NF38 - 6741:United States Pharmacopeia and National Formulary
United States Pharmacopeia, 42(5) (2017)
Acetic acid in peptides
United States Pharmacopeia and National Formulary
United States Pharmacopeia, 42(5), 6741-6741 (2017)
Glacial Acetic Acid Adverse Events: Case Reports and Review of the Literature
Doles W, et al.
Hospital pharmacy (2015)
Takashi Taniguchi et al.
Arthritis & rheumatology (Hoboken, N.J.), 67(2), 517-526 (2014-11-12)
Fli-1, a potential predisposing factor for systemic sclerosis (SSc), is constitutively down-regulated in the lesional skin of patients with SSc by an epigenetic mechanism. To investigate the impact of Fli-1 deficiency on the induction of an SSc phenotype in various
Isabelle Brunet et al.
The Journal of clinical investigation, 124(7), 3230-3240 (2014-06-18)
Autonomic sympathetic nerves innervate peripheral resistance arteries, thereby regulating vascular tone and controlling blood supply to organs. Despite the fundamental importance of blood flow control, how sympathetic arterial innervation develops remains largely unknown. Here, we identified the axon guidance cue

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