A3233
L-Arginase from bovine liver
Protein ≥70 % by biuret, powder
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biological source
bovine liver
Quality Level
form
powder
specific activity
≥100 units/mg protein
composition
Protein, ≥70% biuret
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
Gene Information
cow ... ARG2(518752)
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General description
L-arginase is also called as L-arginine amidinohydrolase. It exists in two forms, such as arginase-1 and arginase-2. Arginase-1 is present in liver cells and arginase-2 is seen usually in extrahepatic tissues like, kidney, brain, skeletal muscle, small intestine and the lactating mammary gland. Arginase -2 is mapped to human chromosome 14q24.1−24.3.
Biochem/physiol Actions
L-Arginase is the major degradative enzyme for arginine; converts arginine to ornithine; deficiency is associated with spasticity and motor dysfunction.
L-arginase hydrolyze L-arginine into L-ornithine and urea, which is the last step of the urea cycle in the liver of ureotelic species. Arginase plays a major role in the mammalian immune system and the enzyme participates in several aspects of inflammation.
Unit Definition
One unit will cause the hydrolysis of 1.0 μmole of L-arginine per minute at pH 9.5 and 37 °C.
signalword
Danger
hcodes
pcodes
Hazard Classifications
Resp. Sens. 1
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Certificates of Analysis (COA)
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Arginase: an emerging key player in the mammalian immune system
Munder M
British Journal of Pharmacology, 158(3), 638-651 (2009)
L-Arginase: a Medically Important Enzyme
Kumar K and Verma N
Research Journal of Pharmacy and Technology, 6(12), 1430-1430 (2013)
Eva Källberg et al.
BMC immunology, 13, 69-69 (2012-12-14)
S100A9 has been shown to be important for the function of so called Myeloid Derived Suppressor Cells (MDSC). Cells with a similar phenotype are also involved in pro-inflammatory processes, and we therefore wanted to investigate the gene expression and function
Yoshinori Narita et al.
Journal of immunology (Baltimore, Md. : 1950), 190(2), 812-820 (2012-12-19)
Evaluation of immune dysfunction during the tumor-bearing state is a critical issue in combating cancer. In this study, we initially found that IL-6, one of the cachectic factors, suppressed CD4(+) T cell-mediated immunity through downregulation of MHC class II by
Abhishek Srivastava et al.
Biochemistry, 52(3), 508-519 (2012-12-29)
Urea producing bimetallic arginases are essential for the synthesis of polyamine, DNA, and RNA. Despite conservation of the signature motifs in all arginases, a nonconserved ¹⁵³ESEEKAWQKLCSL¹⁶⁵ motif is found in the Helicobacter pylori enzyme, whose role is yet unknown. Using
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