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A5508

Sigma-Aldrich

Adenosine 5′-phosphosulfate sodium salt

≥85%

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Synonym(s):
APS
Empirical Formula (Hill Notation):
C10H14N5O10PS
CAS Number:
Molecular Weight:
427.28
MDL number:
PubChem Substance ID:
NACRES:
NA.51

biological source

synthetic (organic)

Quality Level

Assay

≥85%

form

powder

Documentation

see Safety & Documentation for available documents

food allergen

no known allergens

shipped in

dry ice

storage temp.

−20°C

SMILES string

[Na].Nc1ncnc2n(cnc12)C3OC(COP(O)(=O)OS(O)(=O)=O)C(O)C3O

InChI

1S/C10H14N5O10PS.Na.H/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-26(18,19)25-27(20,21)22;;/h2-4,6-7,10,16-17H,1H2,(H,18,19)(H2,11,12,13)(H,20,21,22);;

InChI key

KLZADYTZAADWRW-UHFFFAOYSA-N

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This Item
A1640A1651A0722
assay

≥85%

assay

≥98%

assay

-

assay

≥85% (SDS-PAGE)

form

powder

form

powder

form

powder

form

buffered aqueous solution

shipped in

dry ice

shipped in

-

shipped in

dry ice

shipped in

dry ice

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−70°C

storage temp.

−20°C

documentation

see Safety & Documentation for available documents

documentation

-

documentation

-

documentation

-

Application

Adenosine 5′-phosphosulfate sodium salt has been used in enzyme-linked bioluminescence assay for adenosine triphosphate (ATP) and pyrophosphate quantification.

Biochem/physiol Actions

Adenosine 5′ phosphosulfate (APS) is used as a substrate of adenosine triphosphate (ATP) sulfurylase to complete a PP(i)-recycling loop for exponential ATP amplification in firefly luciferase ATP luminescence assay and other pyrophosphate regeneration-dependent detection assays.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Defective extracellular pyrophosphate metabolism promotes vascular calcification in a mouse model of Hutchinson-Gilford progeria syndrome that is ameliorated on pyrophosphate treatment
Villa BR, et al.
Circulation, 127(24), 2442-2451 (2013)
Novel bioluminescent assay of alkaline phosphatase using adenosine-3?-phosphate-5?-phosphosulfate as substrate and the luciferin-luciferase reaction and its application
Arakawa H, et al.
Analytical biochemistry, 314(2), 206-211 (2003)
Norbert Kiss et al.
Lasers in medical science, 35(8), 1821-1830 (2020-05-07)
Pseudoxanthoma elasticum (PXE, OMIM 264800) is a rare autosomal recessive disorder with ectopic mineralization and fragmentation of elastin fibers. It is caused by mutations of the ABCC6 gene that leads to decreased serum levels of inorganic pyrophosphate (PPi) anti-mineralization factor.
Fumika Mi-Ichi et al.
PLoS neglected tropical diseases, 13(8), e0007633-e0007633 (2019-08-20)
Amoebiasis, caused by Entamoeba histolytica infection, is a global public health problem. However, available drugs to treat amoebiasis are currently limited, and no effective vaccine exists. Therefore, development of new preventive measures against amoebiasis is urgently needed. Here, to develop
Kenji Tanimura et al.
Blood, 125(18), 2835-2844 (2015-03-04)
Antiphospholipid syndrome (APS) is an autoimmune disorder characterized by thrombosis and/or pregnancy complications. β2-glycoprotein I (β2GPI) complexed with phospholipid is recognized as a major target for autoantibodies in APS; however, less than half the patients with clinical manifestations of APS

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