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F2293

Sigma-Aldrich

Follicle Stimulating Hormone from porcine pituitary

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Synonym(s):
FSH, Follitropin, pFSH
CAS Number:
MDL number:
eCl@ss:
42020504
NACRES:
NA.32

form

powder

Quality Level

packaging

pkg of 50 unit per vial

technique(s)

cell culture | mammalian: suitable

solubility

H2O: soluble 50 mg/mL

UniProt accession no.

storage temp.

2-8°C

InChI

1S/C79H125N19O23S/c1-39(2)34-53(90-67(110)51(27-29-57(102)103)87-66(109)49(20-14-15-31-80)86-70(113)54(35-45-18-12-11-13-19-45)92-76(119)63(43(9)99)96-65(108)48(81)38-122)72(115)93-60(40(3)4)75(118)91-55(36-46-23-25-47(101)26-24-46)71(114)88-52(28-30-58(104)105)69(112)97-64(44(10)100)77(120)94-61(41(5)6)74(117)89-50(21-16-32-84-79(82)83)68(111)95-62(42(7)8)78(121)98-33-17-22-56(98)73(116)85-37-59(106)107/h11-13,18-19,23-26,39-44,48-56,60-64,99-101,122H,14-17,20-22,27-38,80-81H2,1-10H3,(H,85,116)(H,86,113)(H,87,109)(H,88,114)(H,89,117)(H,90,110)(H,91,118)(H,92,119)(H,93,115)(H,94,120)(H,95,111)(H,96,108)(H,97,112)(H,102,103)(H,104,105)(H,106,107)(H4,82,83,84)/t43-,44-,48+,49+,50+,51+,52+,53+,54+,55+,56+,60+,61+,62+,63+,64+/m1/s1

InChI key

RPJRYFRWJUYJGY-AYWRSWFDSA-N

Gene Information

human ... FSHR(2492)
pig ... FSHB(396895)

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General description

FSH (follicle stimulating hormone) protein is composed of two subunits- α and β, where α subunit has resemblance to LH, hCG and TSH, which are glycoprotein hormones. α subunit has one glycosylation site and β subunit has two.

Application

Follicle stimulating hormone from porcine pituitary has been used for the in vitro maturation, fertilization and co-culture of cumulus oocyte complex and the co-culture of primary germ and Sertoli cells obtained from adult rat testes.

Biochem/physiol Actions

FSH in involved in the growth of ovarian follicles and steroidogenesis of ovaries. FSHR (follicle stimulating hormone receptor) interacts with FSH in the ovaries, and determines the responsiveness to this hormone. Depressed levels of FSHR result in poor responsiveness and influence folliculogenesis. In Caucasian population, certain polymorphisms in this gene are more commonly found in patients with polycystic ovary syndrome (PCOS).
The α-chain is not active; biological specificity is attributed to the β-chain. Induces maturation of Graafian follicles of the ovary; promotes development of germinal cells in males; activates cytosolic tyrosine kinase.

Other Notes

Two-chain glycoprotein hormone

Unit Definition

One unit is the activity of 1 mg of Armour FSH Standard G-94 by the method of Steelman, S.L., and Pohley, F.M., Endocrinology, 53, 604 (1953).

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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