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F7879

Sigma-Aldrich

Ferritin, cationized from horse spleen

10 mg/mL in 0.15 M NaCl

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CAS Number:
MDL number:
NACRES:
NA.26

biological source

horse spleen

Quality Level

sterility

sterile-filtered

form

liquid

concentration

10 mg/mL in 0.15 M NaCl

technique(s)

cell culture | mammalian: suitable
electron microscopy: suitable

UniProt accession no.

storage temp.

2-8°C

Gene Information

horse ... FTL(100051593)

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F4503C7661C3867
vibrant-m

F4503

Ferritin from equine spleen

vibrant-m

C7661

Collagen from rat tail

concentration

10 mg/mL in 0.15 M NaCl

concentration

-

concentration

-

concentration

>0.5 mg/mL Biuret

technique(s)

cell culture | mammalian: suitable, electron microscopy: suitable

technique(s)

-

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

Quality Level

200

Quality Level

300

Quality Level

200

Quality Level

200

Gene Information

horse ... FTL(100051593)

Gene Information

-

Gene Information

rat ... Col1a1(29393)

Gene Information

rat ... Col1a1(29393)

General description

Ferritin, an iron-storage protein is usually present in the liver and spleen in mammals. Iron and ferritin are distributed relatively same in the eye. Ferritin is made up of heavy and light chains.

Application

A cationic derivative used to label negatively charged cell membranes for visualization by electron microscopy.
Ferritin is an iron storage protein that plays a central role in iron metabolism, and may be elevated in inflammatory or malignant diseases. It has been used in studies as an indicator of body iron supply, but may prove inaccurate in in the presence of chronic inflammation.
Ferritin, cationized from horse spleen has been used:
  • to incubate amoebae (106) in the study, to determine whether trophozoites are able to take up ferritin and internalise this protein for their growth in axenic culture
  • to determine phagosome-lysosome fusion by electron microscopy
  • to label freshly excised chick optic tecta in serum free incubation medium

Biochem/physiol Actions

Ferritin holds iron at its ferric state (Fe3+). The core of ferritin has the capability to hold 4500 iron molecules. It is essential to store iron in vertebrates. Ferritin is also essential to store and transport iron in invertebrates. It plays a key role in dietary iron absorption.

Preparation Note

Prepared by coupling horse spleen ferritin with N,N-dimethyl-1,3-propanediamine (DMPA).

Storage Class

10 - Combustible liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable


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