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F9786

Sigma-Aldrich

Fibroblast Growth Factor-Basic Heparin Stabilized human

FGF-Basic, recombinant, expressed in E. coli, sterile-filtered, aqueous solution, suitable for cell culture

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Synonym(s):
rhbFGF
CAS Number:
MDL number:
NACRES:
NA.77

biological source

human

Quality Level

recombinant

expressed in E. coli

sterility

sterile-filtered

form

aqueous solution

potency

0.03-3.0 ng/mL ED50/EC50

quality

endotoxin tested

packaging

pkg of 1 and 5 mL

technique(s)

cell culture | mammalian: suitable

UniProt accession no.

storage temp.

2-8°C

Gene Information

human ... FGF2(2247)

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F5542F1168GF003AF
Sigma-Aldrich

F1168

Fibroblast Growth Factor-9 human

recombinant

expressed in E. coli

recombinant

expressed in E. coli

recombinant

expressed in baculovirus infected Sf21 cells

recombinant

-

biological source

human

biological source

human

biological source

human

biological source

human

form

aqueous solution

form

lyophilized powder

form

lyophilized powder

form

-

packaging

pkg of 1 and 5 mL

packaging

pkg of 25 μg

packaging

pkg of 25 μg

packaging

-

Gene Information

human ... FGF2(2247)

Gene Information

human ... FGF1(2246)

Gene Information

human ... FGF9(2254)

Gene Information

-

General description

Fibroblast growth factor 2 (FGF2), a canonical member, belongs to the fibroblast growth factor family.

Application

Fibroblast Growth Factor-Basic Heparin Stabilized human has been used to culture Brown Norway rat yolk sac epithelial cells transformed with mouse sarcoma virus (BN/MSV). It has also been used in the preparation of serum-free mouse tubal epithelium growth medium (M-TE-GM) to culture primary tubal epithelium (TE) cells.

Biochem/physiol Actions

Fibroblast growth factor 2 (FGF2) participates in tissue development and repair. It is also involved in embryonic development, angiogenesis, bone regeneration, stem cell self-renewal, and wound healing. The basic fibroblast growth factor (bFGF) plays a key role in the progression and maintenance of the nervous system. FGF2 binds to the FGF receptor (FGFR) and activates the extracellular signal-regulated kinase (ERK) pathway, which controls cellular behavior, using heparan sulfates (HS)/heparin as a cofactor. bFGF stimulates cell proliferation, differentiation, and migration in a variety of cell types. In cultured astrocytes from rat brain, recombinant human basic fibroblast growth factor (rhbFGF) may induce nerve growth factor (NGF) secretion. It is the heparin stabilized form of a natural mitogenic growth factor used in cell culture applications to study cell signaling and to promote fibroblast and endothelial cell growth and survival.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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