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I6383

Sigma-Aldrich

Insulin Chain B Oxidized from bovine pancreas

≥80% (HPLC), powder

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Empirical Formula (Hill Notation):
C157H232N40O47S2
CAS Number:
Molecular Weight:
3495.89
MDL number:

sterility

non-sterile

Quality Level

assay

≥80% (HPLC)

form

powder

mol wt

3496 Da by calculation (Average Mass)

UniProt accession no.

shipped in

ambient

storage temp.

−20°C

InChI

1S/C157H232N40O47S2/c1-79(2)57-104(181-130(211)86(15)172-136(217)103(50-53-125(209)210)180-152(233)127(84(11)12)194-148(229)107(60-82(7)8)184-145(226)113(67-95-70-165-78-171-95)189-150(231)115(74-198)176-123(206)73-169-133(214)116(75-245(239,240)241)191-140(221)105(58-80(3)4)182-144(225)112(66-94-69-164-77-170-94)188-138(219)102(48-51-119(160)202)178-146(227)114(68-120(161)203)190-153(234)126(83(9)10)193-131(212)98(159)61-89-31-21-18-22-32-89)139(220)185-110(64-92-40-44-96(200)45-41-92)142(223)183-106(59-81(5)6)147(228)195-128(85(13)14)154(235)192-117(76-246(242,243)244)134(215)168-71-121(204)174-101(49-52-124(207)208)137(218)177-99(38-29-55-166-157(162)163)132(213)167-72-122(205)175-108(62-90-33-23-19-24-34-90)141(222)186-109(63-91-35-25-20-26-36-91)143(224)187-111(65-93-42-46-97(201)47-43-93)149(230)196-129(88(17)199)155(236)197-56-30-39-118(197)151(232)179-100(37-27-28-54-158)135(216)173-87(16)156(237)238/h18-26,31-36,40-47,69-70,77-88,98-118,126-129,198-201H,27-30,37-39,48-68,71-76,158-159H2,1-17H3,(H2,160,202)(H2,161,203)(H,164,170)(H,165,171)(H,167,213)(H,168,215)(H,169,214)(H,172,217)(H,173,216)(H,174,204)(H,175,205)(H,176,206)(H,177,218)(H,178,227)(H,179,232)(H,180,233)(H,181,211)(H,182,225)(H,183,223)(H,184,226)(H,185,220)(H,186,222)(H,187,224)(H,188,219)(H,189,231)(H,190,234)(H,191,221)(H,192,235)(H,193,212)(H,194,229)(H,195,228)(H,196,230)(H,207,208)(H,209,210)(H,237,238)(H4,162,163,166)(H,239,240,241)(H,242,243,244)/t86-,87-,88+,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,126-,127-,128-,129-/m0/s1

InChI key

CZJQESISDHGFTC-DQCCOYHDSA-N

Gene Information

cow ... INS(280829)

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1 of 4

This Item
I1764I1633I5500
Sigma-Aldrich

I1764

Insulin Chain B Oxidized from bovine pancreas

Essential+ Grade
Insulin from bovine pancreas ≥25 USP units/mg (HPLC), powder

I5500

Insulin from bovine pancreas

-
Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

form

powder

form

-

form

powder

form

powder

shipped in

ambient

shipped in

-

shipped in

ambient

shipped in

ambient

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

−20°C

Gene Information

cow ... INS(280829)

Gene Information

cow ... INS(280829)

Gene Information

cow ... INS(280829)

Gene Information

cow ... INS(280829)

Amino Acid Sequence

Phe-Val-Asn-Gln-His-Leu-Cys(SO3H)-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cys(SO3H)-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala

General description

Insulin is made up of two polypeptide chains (A and B) linked together by two disulfide linkages. Chain A and B are composed of 21 amino acids and 30 amino acids, respectively.

Application

Insulin Chain B Oxidized from bovine pancreas has been used:
  • as a matrix-assisted laser desorption/ionization (MALDI)-mass spectrometry (MS) calibration standard
  • in electrochemical impedance spectroscopy and quartz crystal nanobalance (EQCN) studies of insulin adsorption on platinum
  • as an internal standard to quantify insulin chain B residue in protein samples

Biochem/physiol Actions

Insulin regulates the cellular uptake, utilization, and storage of glucose, amino acids, and fatty acids. It inhibits the breakdown of glycogen, protein, and fat. The β chain is a substrate for carboxypeptidase Y.

Preparation Note

Prepared by modification of Sanger, F., et al.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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Customers Also Viewed

Slide 1 of 7

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L He et al.
Journal of mass spectrometry : JMS, 34(9), 909-914 (1999-09-24)
Matrix-assisted laser desorption/ionization (MALDI) mass spectra were obtained from single particles injected directly into a time-of-flight mass spectrometer. Aerosol particles were generated at atmospheric pressure using a piezoelectric single-particle generator or a pneumatic nebulizer and introduced into the mass spectrometer
Carol E Parker et al.
Molecular biotechnology, 20(1), 49-62 (2002-03-06)
Proteolytic digestion of proteins bound to immobilized antibodies, combined with matrix assisted laser desorption (MALDI) mass spectrometric identification of the affinity-bound peptides, can be a powerful technique for epitope determination. Binding of the protein to the antibody is done while
Electrochemical impedance spectroscopy and quartz crystal nanobalance (EQCN) studies of insulin adsorption on Pt
Wright JEI, et al.
Journal of Electroanalytical Chemistry, 564, 185-197 (2004)
Johansen, J.T., et al.
Carlsberg Research Communications, 41, 1-1 (1976)
Fractionation of oxidized insulin.
F Sanger
The Biochemical journal, 44(1), 126-128 (1949-01-01)

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