L7134

Luteinizing hormone releasing hormone human acetate salt

≥98% (HPLC), powder

• Synonym(s): Gonadoliberin, Gonadotropin releasing hormone, LH-RH
• Empirical Formula (Hill Notation): C₅₅H₇₅N₁₇O₁₃
• CAS Number: 71447-49-9
• Molecular Weight: 1182.29
• MDL number: MFCD00133489
• PubChem Substance ID: 329817648
• NACRES: NA.32

Properties

• Quality Level: 200
• Assay: ≥98% (HPLC)
• form: powder
• mol wt: M_r 1182.33
• UniProt accession no.: P01148
• storage temp.: −20°C
• SMILES string: CC(O)=O.CC(O)=O.CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc4c[nH]cn4)NC(=O)[C@@H]5CCC(=O)N5)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N6CCC[C@H]6C(=O)NCC(N)=O
• InChI: 1S/C55H75N17O13.2C2H4O2/c1-29(2)19-38(49(80)67-37(9-5-17-60-55(57)58)54(85)72-18-6-10-43(72)53(84)62-25-44(56)75)66-46(77)26-63-47(78)39(20-30-11-13-33(74)14-12-30)68-52(83)42(27-73)71-50(81)40(21-31-23-61-35-8-4-3-7-34(31)35)69-51(82)41(22-32-24-59-28-64-32)70-48(79)36-15-16-45(76)65-36;2*1-2(3)4/h3-4,7-8,11-14,23-24,28-29,36-43,61,73-74H,5-6,9-10,15-22,25-27H2,1-2H3,(H2,56,75)(H,59,64)(H,62,84)(H,63,78)(H,65,76)(H,66,77)(H,67,80)(H,68,83)(H,69,82)(H,70,79)(H,71,81)(H4,57,58,60);2*1H3,(H,3,4)/t36-,37-,38-,39-,40-,41-,42-,43-;;/m0../s1
• InChI key: QOVPLTBEZAJSHY-VIRDRFNDSA-N
• Gene Information: human ... GNRH1(2796)

Description

Amino Acid Sequence

Glp-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2

Application

Luteinizing hormone releasing hormone human acetate salt has been used:

• for synchronization of the ovulations
• for pre-absorption of the anti-GnRH antibody in staining procedures
• to study pituitary sensitivity to GnRH in presence of endocrine disrupting compound

Biochem/physiol Actions

Hypothalamic peptide that stimulates release of gonadotrophins from anterior pituitary, thus regulating reproductive functions.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Components

pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH₂

Other Notes

free peptide

Lyophilized from 0.5% acetic acid

Safety Information

• Pictograms: GHS08
• Signal Word: Danger
• Hazard Statements: H360
• Precautionary Statements: P201 - P308 + P313
• Hazard Classifications: Repr. 1B
• Storage Class Code: 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves