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M7398

Sigma-Aldrich

Monoclonal Anti-β2-Microglobulin antibody produced in mouse

clone BM-63, ascites fluid

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MDL number:
NACRES:
NA.41

biological source

mouse

conjugate

unconjugated

antibody form

ascites fluid

antibody product type

primary antibodies

clone

BM-63, monoclonal

mol wt

antigen 12 kDa

contains

15 mM sodium azide

species reactivity

human

technique(s)

indirect ELISA: 1:1000
indirect immunofluorescence: 1:500 using human PBL′s

isotype

IgG1

UniProt accession no.

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... B2M(567)

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This Item
SAB4700013F4639C7207
antibody form

ascites fluid

antibody form

purified immunoglobulin

antibody form

ascites fluid

antibody form

ascites fluid

conjugate

unconjugated

conjugate

phycoerythrin (R-PE) conjugate

conjugate

unconjugated

conjugate

unconjugated

biological source

mouse

biological source

mouse

biological source

mouse

biological source

mouse

clone

BM-63, monoclonal

clone

B2M-01, monoclonal

clone

FG-21, monoclonal

clone

15B8, monoclonal

Gene Information

human ... B2M(567)

Gene Information

human ... B2M(567)

Gene Information

human ... FGA(2243), FGB(2244), FGG(2266)

Gene Information

human ... CTNNB1(1499)

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General description

β-2-microglobulin is part of the human leukocyte antigen, where it represents the light chain. It is expressed on cell membranes and is made up of 99 amino acids. β-2-microglobulin is part of the immunoglobulin superfamily. β−2-Microglobulin is a membrane glycoprotein of mammalian nucleated cells including lymphocytes.
Monoclonal anti-β-2-Microglobulin (mouse IgG1 isotype) is derived from the hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse.

Immunogen

human β2-microglobulin and a lysate of a lymphoblastoid cell line.

Application

Monoclonal Anti-β2-Microglobulin antibody produced in mouse has been used in ELISA and immunofluorescent labelling.

Biochem/physiol Actions

β-2-microglobulin acts as a tumor marker and has been shown to be associated with dialysis-related amyloidosis. It may function as a structural part of the MHC Class I molecule.
Microglobulin may be elevated in the serum or urine of patients with systemic lupus erythematosus (SLE), rheumatoid arthritis, metal toxications, some viral infections and possibly malignant disorders and AIDS.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class

10 - Combustible liquids

wgk_germany

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable


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W Pruzanski et al.
The Biochemical journal, 309 ( Pt 2), 461-464 (1995-07-15)
The acute-phase proteins serum amyloid A protein (SAA) and secretory phospholipase A2 (sPLA2) are simultaneously expressed during inflammatory conditions. SAA associates with high-density lipoprotein (HDL) altering its physicochemical composition. We found that purified acute-phase SAA, but not the constitutive form
The production, purification and crystallization of a soluble form of the nonclassical MHC HLA-G: the essential role of cobalt
Clements CS, et al.
Acta Crystallographica Section F, Structural Biology and Crystallization Communications, 62(1), 70-73 (2006)
Justin T H Chan et al.
Science advances, 4(11), eaar7653-eaar7653 (2018-11-13)
Memory B cells and plasma cells are antigen-experienced cells tasked with the maintenance of humoral protection. Despite these prominent functions, definitive cell surface markers have not been identified for these cells. We report here the isolation and characterization of the
D L Clemens et al.
Infection and immunity, 61(7), 2803-2812 (1993-07-01)
Legionella pneumophila is a facultative intracellular pathogen that parasitizes host mononuclear phagocytes. Cell-mediated immunity is pivotal to host defense against L. pneumophila, and the infected host cell may play a central role in processing and presenting parasite antigens to lymphocytes
G Diedrich et al.
Journal of immunology (Baltimore, Md. : 1950), 166(3), 1703-1709 (2001-02-13)
Heterodimers of MHC class I glycoprotein and beta(2)-microglobulin (beta(2)m) bind short peptides in the endoplasmic reticulum (ER). Before peptide binding these molecules form part of a multisubunit loading complex that also contains the two subunits of the TAP, the transmembrane

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