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MAK014

Sigma-Aldrich

Glucose-6-Phosphate Assay Kit

sufficient for 100 colorimetric tests

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NACRES:
NA.84

usage

sufficient for 100 colorimetric tests

detection method

colorimetric

relevant disease(s)

hematological disorder

storage temp.

−20°C

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MAK021MAK015MAK020
Glucose-6-Phosphate Assay Kit sufficient for 100 colorimetric tests

MAK014

Glucose-6-Phosphate Assay Kit

Fructose-6-Phosphate Assay Kit sufficient for 100 fluorometric tests

MAK020

Fructose-6-Phosphate Assay Kit

usage

sufficient for 100 colorimetric tests

usage

sufficient for 100 fluorometric tests

usage

sufficient for 100 colorimetric tests

usage

sufficient for 100 fluorometric tests

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

relevant disease(s)

hematological disorder

relevant disease(s)

cancer; hematological disorder

relevant disease(s)

cancer; hematological disorder

relevant disease(s)

cancer

General description

Glucose 6-phosphate (G6P) is a key metabolic intermediate that enters either metabolic pathways or storage. G6P is generated when glucose is phosphorylated by hexokinase or glucokinase or by the conversion of glucose-1-phosphate by phosphoglucomutase during glycogenolysis. G6P lies at the beginning of both glycolysis and the pentose phosphate pathways. It also can be stored as glycogen when blood glucose levels are high.

Application

Glucose-6-phosphate assay kit has been used in:

  • glucose 6-phosphate (G6P) assay
  • quantification of glucose-6-phosphate (G6P) and fructose-6-phosphate (F6P)
  • metabolite analysis

Suitability

Suitable for quantifying Glucose-6-Phosphate in a variety of samples.

Principle

G6P is utilized by Glucose-6-phosphate dehydrogenase to generate reducing equivalents in the form of NADPH. This is particularly important in red blood cells where a G6PDH deficiency leads to hemolytic anemia. G6P is determined by an enzyme assay, which results in a colorimetric (450 nm) product, proportional to the G6P present. Typical sensitivities of detection are between 1-30 nmoles.

replaced by

pictograms

CorrosionHealth hazard

signalword

Danger

Hazard Classifications

Eye Dam. 1 - Resp. Sens. 1 - Skin Corr. 1B

Storage Class

8A - Combustible, corrosive hazardous materials

wgk_germany

WGK 3


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Articles

We presents an article about the Warburg effect, and how it is the enhanced conversion of glucose to lactate observed in tumor cells, even in the presence of normal levels of oxygen. Otto Heinrich Warburg demonstrated in 1924 that cancer cells show an increased dependence on glycolysis to meet their energy needs, regardless of whether they were well-oxygenated or not.

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