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N3279

Sigma-Aldrich

Monoclonal Anti-Nerve Growth Factor-β antibody produced in mouse

clone 25623, purified immunoglobulin, lyophilized powder

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Synonym(s):
Anti-NGF-β
MDL number:
NACRES:
NA.41

biological source

mouse

Quality Level

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

25623, monoclonal

form

lyophilized powder

species reactivity

human, rat, mouse

technique(s)

capture ELISA: 2-8 μg/mL (detection antibody at 0.1-0.4 μg/ml)
neutralization: 0.1-0.4 μg/mL

impurities

endotoxin, tested

isotype

IgG1

UniProt accession no.

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... NGF(4803)
mouse ... Ngf(18049)

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This Item
N6655MABN2322N8773
conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

Gene Information

human ... NGF(4803)
mouse ... Ngf(18049)

Gene Information

human ... NGF(4803)
mouse ... Ngf(18049)

Gene Information

mouse ... Ngf(18049)

Gene Information

rat ... Ngf(310738)

species reactivity

human, rat, mouse

species reactivity

mouse, human

species reactivity

chicken, human, mouse

species reactivity

rat

biological source

mouse

biological source

rabbit

biological source

rat

biological source

goat

clone

25623, monoclonal

clone

polyclonal

clone

α D11, monoclonal

clone

polyclonal

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Immunogen

recombinant human NGF-β.

Biochem/physiol Actions

Nerve Growth factor (NGF) is a growth factor that is essential for the development and maintenance of the nervous system. NGF is composed of three non-covalently linked α, β and γ subunits. The β subunit is responsible for the biological functions of NGF. Nerve growth factor (NGF) binds to either to NGF receptor (NGFR) or the Trk receptor and can elicit biological responses through each of the receptors independently. NGF is important in the survival and differentiation of neurons and neural crest-derived cells during embryonic and early postnatal development and maintenance of peripheral neurons. NGF is also implicated in inflammation and allergic reactions.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing carbohydrates.

Preparation Note

Purified using Protein G.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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Josemberg S Baptista et al.
PloS one, 15(1), e0228155-e0228155 (2020-01-28)
Intervertebral disc (IVD) degeneration is a remodeling process mediated by several growth factors and cytokines. This process has been extensively studied in vitro and with pathologic specimens obtained during surgery for scoliosis or back pain. However, the occurrence and temporal
Seong Hoon Seo et al.
The Journal of investigative dermatology, 140(11), 2199-2209 (2020-04-06)
Itch in atopic dermatitis (AD) is aggravated under warm conditions. Transient receptor potential vanilloid (TRPV) 3, a member of the thermosensitive transient receptor potential channels, is activated by innocuous heat and is abundantly expressed in keratinocytes. The potential role of
Wolfgang Andreas Nockher et al.
The Journal of allergy and clinical immunology, 117(3), 583-589 (2006-03-09)
Understanding the complex pathophysiology of allergic diseases has been a main challenge of clinical and experimental research for many years. It is well known that the allergic inflammation triggers neuronal dysfunction and structural changes in the diseased tissues such as
Y Indo
Clinical genetics, 82(4), 341-350 (2012-08-14)
Congenital insensitivity to pain with anhidrosis (CIPA) is an autosomal recessive genetic disorder characterized by insensitivity to pain, anhidrosis (the inability to sweat) and mental retardation. Nerve growth factor (NGF) is a well-known neurotrophic factor essential for the survival and
C D Mills et al.
European journal of pain (London, England), 17(4), 469-479 (2012-08-24)
Injection of nerve growth factor (NGF) produces mechanical and thermal hypersensitivity in rodents and humans. Treatment with sequestering antibodies demonstrates the importance of NGF in various pain states, with efficacy seen in a number of animal pain models and in

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