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P1941

Sigma-Aldrich

Poly(D,L-lactide-co-glycolide)

lactide:glycolide (75:25), mol wt 66,000-107,000

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Synonym(s):
LACTEL® B6007-1, PLGA
Linear Formula:
[C3H4O2]x[C2H2O2]y
MDL number:
MFCD00131930
PubChem Substance ID:
24898256
NACRES:
NA.26

form

pellets

Quality Level

100

feed ratio

lactide:glycolide (75:25)

mol wt

66,000-107,000

storage temp.

−20°C

SMILES string

OCC(O)=O.CC(O)C(O)=O

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This Item
P2191P2066802182
Poly(D,L-lactide-co-glycolide) lactide:glycolide (75:25), mol wt 66,000-107,000

Sigma-Aldrich

P1941

Poly(D,L-lactide-co-glycolide)

Poly(D,L-lactide-co-glycolide) lactide:glycolide (50:50), mol wt 30,000-60,000

Sigma-Aldrich

P2191

Poly(D,L-lactide-co-glycolide)

Poly(D,L-lactide-co-glycolide) lactide:glycolide 65:35, Mw 40,000-75,000

Sigma-Aldrich

P2066

Poly(D,L-lactide-co-glycolide)

Poly(D,L-lactide-co-glycolide) lactide:glycolide (50:50), ester terminated, average Mw 100,000

Sigma-Aldrich

802182

Poly(D,L-lactide-co-glycolide)

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

2-8°C

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

feed ratio

lactide:glycolide (75:25)

feed ratio

lactide:glycolide (50:50)

feed ratio

lactide:glycolide 65:35

feed ratio

lactide:glycolide (50:50)

mol wt

66,000-107,000

mol wt

30,000-60,000

mol wt

Mw 40,000-75,000

mol wt

average Mw 100,000

General description

The product is an amorphous solid with a transition temperature (Tg) in the range of 45-50°C. It is soluble in most organic solvents such as methylene chloride, tetrahydrofuran, ethyl acetate, acetone, chloroform, and hexafluoroispropanol.

Application

Poly(D,L-lactide-co-glycolide) is a synthetic amino acid that has been used to deliver macromolecular therapeutics.

Features and Benefits

Controlled release of bioactive agents, sutures and bioabsorbable implantable devices.

Physical form

Biocompatible, biodegradable polymer.

Legal Information

Lactel is a registered trademark of Evonik Corp

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Fabrication of amorphous strontium polyphosphate microparticles that induce mineralization of bone cells in vitro and in vivo
Werner E.G.Muller
Acta Biomaterialia, 50, 89-101 (2017)
Robert M Stefani et al.
Acta biomaterialia, 102, 326-340 (2019-12-06)
Articular cartilage defects are a common source of joint pain and dysfunction. We hypothesized that sustained low-dose dexamethasone (DEX) delivery via an acellular osteochondral implant would have a dual pro-anabolic and anti-catabolic effect, both supporting the functional integrity of adjacent
Shu-Chun Chuang et al.
Parasites & vectors, 6, 34-34 (2013-02-13)
Current development efforts of subunit vaccines against Toxoplasma gondii, the etiological agent of toxoplasmosis, have been focused mainly on tachyzoite surface antigen 1 (SAG1). Since microparticles made from poly (lactide-co-glycolide) (PLG) polymers have been developed as safe, potent adjuvants or
Vanna Sanna et al.
International journal of nanomedicine, 7, 5501-5516 (2012-10-25)
Resveratrol, like other natural polyphenols, is an extremely photosensitive compound with low chemical stability, which limits the therapeutic application of its beneficial effects. The development of innovative formulation strategies, able to overcome physicochemical and pharmacokinetic limitations of this compound, may
Rongcai Liang et al.
International journal of pharmaceutics, 454(1), 344-353 (2013-07-23)
Peptide or protein degradation often occurs when water flows into the dosage form. The aim of this study was to investigate the effect of water on exenatide acylation in poly(lactide-co-glycolide) (PLGA) microspheres. Exenatide-loaded PLGA microspheres were incubated at different relative
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