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Sigma-Aldrich

Resomer® RG 502 H, Poly(D,L-lactide-co-glycolide)

acid terminated, viscosity 0.16-0.24 dL/g 

Synonym(s):

PLGA

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About This Item

Linear Formula:
[C3H4O2]x[C2H2O2]y
CAS Number:
26780-50-7
UNSPSC Code:
12162002
NACRES:
NA.23

form

amorphous

feed ratio

lactide:glycolide 50:50

degradation timeframe

<3 months

viscosity

0.16-0.24 dL/g

transition temp

Tg 42-46 °C

storage temp.

2-8°C

InChI

1S/C6H8O4.C4H4O4/c1-3-5(7)10-4(2)6(8)9-3;5-3-1-7-4(6)2-8-3/h3-4H,1-2H3;1-2H2

InChI key

LCSKNASZPVZHEG-UHFFFAOYSA-N

Application

Poly(D,L-lactide-co-glycolide) (PLGA) canbe used:

  • In the formulation ofa non-aqueous drug delivery system for H2S donors to aid thesustained release of the drug.
  • To prepare a polymer blend containing Ganciclovir-loaded microspheresdispersed in PLGA–PEG–PLGA polymer gel. This formulation can be used as asustained delivery system for Ganciclovir drug.
It can also be used to fabricate NO-releasingglucose and lactate sensors.

Legal Information

Product of Evonik
RESOMER is a registered trademark of Evonik Rohm GmbH

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Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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A Patil et al.
AAPS PharmSciTech, 18(6), 2291-2302 (2017-01-20)
Hydrogen sulfide (H2S) targets both underlying factors in glaucoma pathogenesis by reducing elevated intraocular pressure (IOP) and providing retinal neuroprotection, whereas the current clinical approaches targets only reducing IOP. Therefore, H2S could be a potential superior candidate for glaucoma pharmacotherapy.
Diazeniumdiolate-doped poly (lactic-co-glycolic acid)-based nitric oxide releasing films as antibiofilm coatings.
Cai W,et al.
Biomaterials, 33(32), 7933-7944 (2012)
Z Zhuang et al.
Journal of dental research, 98(2), 200-208 (2018-11-06)
Periodontitis is characterized by the progressive destruction of tooth-supporting alveolar bone, which is mainly caused by chronic inflammation in response to persistent bacterial insult. It has recently become clear that the pathogenesis of periodontitis is associated with a high ratio
Qinyi Yan et al.
Biosensors & bioelectronics, 26(11), 4276-4282 (2011-05-20)
Intravenous amperometric needle-type enzymatic glucose/lactate sensors intended for continuous monitoring are prepared with a novel nitric oxide (NO) releasing layer to improve device hemocompatibility. To create an underlying NO release coating, the sensors with immobilized enzymes (either glucose oxidase or
Sridhar Duvvuri et al.
Journal of controlled release : official journal of the Controlled Release Society, 108(2-3), 282-293 (2005-10-19)
The purpose of this work is to develop empirical equations for describing the in vitro ganciclovir (GCV) release from PLGA microspheres and also to develop and characterize a formulation containing GCV loaded PLGA microspheres dispersed in thermogelling PLGA-PEG-PLGA polymer gel.
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