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P9389

Sigma-Aldrich

Poly(deoxyguanylic-deoxycytidylic) acid sodium salt

double stranded, alternating copolymer

Synonym(s):

Poly(dG-dC) • Poly(dG-dC)

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About This Item

CAS Number:
90385-88-9
MDL number:
MFCD00131968
UNSPSC Code:
41106305
NACRES:
NA.51

biological source

synthetic (organic)

Quality Level

200

form

powder or solid

storage temp.

−20°C

General description

Poly(deoxyguanylic-deoxycytidylic) acid (poly(dG-dC)) undergoes salt dependent conformational transition. Under high-salt, it exists as a left-handed double helix and at low-salt it displays B-DNA conformation. However on immobilization, poly(dG-dC) takes up A DNA form.

Application

Poly(deoxyguanylic-deoxycytidylic) acid (Poly(dG-dC) • Poly(dG-dC)) is an alternating copolymer, self-complementary, double-stranded DNA model for conformational studies of DNA structure dynamics and drug interaction.
Poly(deoxyguanylic-deoxycytidylic) acid sodium salt has been used:
  • in electrophoretic mobility shift assay of transcription factor IIIB complex
  • as synthetic copolymers for circular dichroism (CD) spectroscopy studies
  • as a positive control in liquid scintillation counting

Other Notes

Alternating copolymer; self-complementary, form double-stranded complex

Unit Definition

One unit will yield an A260 of 1.0 in 1.0 ml 20 mM sodium phosphate/100 mM NaCl, pH 7.0 (1cm light path).

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Sigma-Aldrich

P9582

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TFIIIB subunit locations on U6 gene promoter DNA mapped by site-specific protein-DNA photo-cross-linking
Kang JJ, et al.
Febs Letters, 590(10), 1488-1497 (2016)
Salt-dependent dynamic structure of poly (dG-dC) textperiodcentered poly (dG-dC)
Ramstein J and Leng M
Nature, 288(5789), 413-413 (1980)
Poly (dG)-poly (dC) DNA appears shorter than poly (dA)-poly (dT) and possibly adopts an A-related conformation on a mica surface under ambient conditions
Borovok N, et al.
Febs Letters, 581(30), 5843-5846 (2007)
Genomic DNA methylation decreases in response to moderate folate depletion in elderly women-
Rampersaud GC, et al.
American Journal of Clinical Nutrition, 72(4), 998-1003 (2000)
Natasha McStay et al.
Nucleic acids research, 45(2), 527-540 (2016-12-03)
Herein we report the synthesis of tripodal C
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