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PRS3627

Sigma-Aldrich

Anti-LAMP-2 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-Lysosomal-associated membrane protein 2

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5 G
$307.80

$307.80

List Price$324.00

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5 G
$307.80

About This Item

MDL number:
MFCD01864612
UNSPSC Code:
12352203
NACRES:
NA.41

$307.80

List Price$324.00

In StockDetails

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

mouse, human

technique(s)

immunocytochemistry: suitable
indirect ELISA: suitable
western blot: suitable

UniProt accession no.

P17047

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724807724815725668
Poly(N-isopropylacrylamide), carboxylic acid terminated average Mn 10,000

724459

Poly(N-isopropylacrylamide), carboxylic acid terminated

Poly(N-isopropylacrylamide), carboxylic acid terminated average Mn 5,000

724807

Poly(N-isopropylacrylamide), carboxylic acid terminated

Poly(N-isopropylacrylamide), carboxylic acid terminated average Mn 2,000

724815

Poly(N-isopropylacrylamide), carboxylic acid terminated

Poly(N-isopropylacrylamide), N-hydroxysuccinimide (NHS) ester terminated average Mn 2,000

725668

Poly(N-isopropylacrylamide), N-hydroxysuccinimide (NHS) ester terminated

mp

>300 °C

mp

>300 °C

mp

>300 °C

mp

>300 °C

mol wt

average Mn 10,000 by GPC (THF w/ 5%TEA, PS, RI)

mol wt

average Mn 5,000

mol wt

average Mn 2,000

mol wt

average Mn 2,000

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

General description

Lamp2 (lysosome-associated membrane protein gene)is located in the lysosomal lumen and lysosomal membrane. However upon chronic acidosis in the tumour microenvironment, it is found to be present in the plasma membrane.

Immunogen

a 17 amino acid peptide from near the center of human LAMP-2.

Application

Anti-LAMP-2 antibody has been used in immunofluorescence and western blot.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunofluorescence (1 paper)

Biochem/physiol Actions

LAMP2 (lysosome-associated membrane protein gene) preserves lysosomal membranes from acid proteolysis. It serves as an acidity biomarker in spheroids and xenografts. It also has some role in maturation of autophagic vacuoles and cell-cell or cell-extracellular matrix adhesion. Reduction of LAMP2 (lysosome-associated membrane protein gene) can increase acidosis-mediated toxicity. Mutation in LAMP2 can cause cardiomyopathy in young patients.

Linkage

The action of this antibody can be blocked using blocking peptide SBP3627.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

  • Specification Sheet

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    Certificates of Analysis (COA)

    Lot/Batch Number
    36271501
    36270503
    3627-0503

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    Inter-domain tagging implicates caveolin-1 in insulin receptor trafficking and Erk signaling bias in pancreatic beta-cells
    Boothe T, et al.
    Molecular Metabolism, 5(5), 366-378 (2016)
    Tobias Boothe et al.
    Molecular metabolism, 5(5), 366-378 (2016-04-26)
    The role and mechanisms of insulin receptor internalization remain incompletely understood. Previous trafficking studies of insulin receptors involved fluorescent protein tagging at their termini, manipulations that may be expected to result in dysfunctional receptors. Our objective was to determine the
    Bortezomib enhances cancer cell death by blocking the autophagic flux through stimulating ERK phosphorylation
    Kao C, et al.
    Cell Death & Disease, 5 (2014)
    Chronic acidosis in the tumour microenvironment selects for overexpression of LAMP2 in the plasma membrane
    Damaghi M, et al.
    Nature Communications, 6:8752 (2015)
    Unique properties of lamp2a compared to other lamp2 isoforms
    Cuervo AM and Dice JF
    Journal of Cell Science, 113 Pt 24, 4441-4450 (2000)
    View All Related Papers

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